Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?.
10.5213/inj.2015.19.3.164
- Author:
Ayla ESER
1
;
Eylem UNLUBILGIN
;
Fatih HIZLI
;
Muradiye ACAR
;
Zeynep KAMALAK
;
Aydin KOSUS
;
Nermin KOSUS
;
Deniz HIZLI
;
Esra GUNDUZ
Author Information
1. Department of Obstetrics and Gynecology, Turgut Ozal University Medical School, Ankara, Turkey. aylaacar76@yahoo.com.tr
- Publication Type:Original Article
- Keywords:
Extracellular Matrix;
Fibrillin;
Pelvic Organ Prolapse
- MeSH:
Birth Weight;
Cystocele;
Extracellular Matrix;
Female;
Gene Expression;
Humans;
Hysterectomy;
Marfan Syndrome;
Menopause;
Parturition;
Pelvic Floor Disorders;
Pelvic Organ Prolapse*;
Prolapse;
Real-Time Polymerase Chain Reaction;
Rectocele;
Urinary Incontinence;
Uterine Prolapse
- From:International Neurourology Journal
2015;19(3):164-170
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse. METHODS: Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision. RESULTS: Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P=0.018) and menopause (P=0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P=0.006). CONCLUSIONS: The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin-1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations.
