Association between nonalcoholic fatty liver disease and colorectal neoplasms

VernacularTitle:非酒精性脂肪性肝病与结直肠肿瘤的相关性
Author: Xiangqian HUANG ¹ ; Xiaomeng YAN ¹ ; Mingda ZHANG ¹ ; Jing WU ^{2
,

3
,

4
,

5} ; Jianhong CHEN ¹
Author Information

1. Department of Gastroenterology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
2. Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University
3. National Clinical Research Center for Digestive Diseases
4. Beijing Digestive Disease Center
5. Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China
Publication Type:Reviews
Keywords: Non-alcoholic Fatty Liver Disease; Colorectal Neoplasms; Pathologic Processes
From: Journal of Clinical Hepatology 2021;37(12):2947-2950
CountryChina
Language:Chinese
Abstract: Nonalcoholic fatty liver disease (NAFLD) is considered the liver manifestation of metabolic syndrome and is closely associated with the development and progression of colorectal neoplasms. This article reviews the association of NAFLD with colorectal adenoma (CRA) and colorectal cancer (CRC) and possible mechanism, and it is believed that NAFLD promotes the development of CRA and CRC and affects their prognosis, and various factors, such as insulin resistance, adipocytokine, inflammatory response, intestinal flora, and immunity, may be involved in this process.