Biopathway construction of plant natural products
10.16438/j.0513-4870.2021-1637
- VernacularTitle:植物天然产物途径创建
- Author:
Xiu-yu LIU
1
,
2
;
Ling-long LUO
1
;
Ying MA
1
;
Jun-ling BU
1
;
Zhi-min HU
1
;
Shu-fu SUN
1
,
3
;
Guang-hong CUI
1
;
Jin-fu TANG
1
;
Juan GUO
1
;
Lu-qi HUANG
1
Author Information
1. State Key Laboratory of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2. School of Pharmaceutical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
3. School of Pharmaceutical Sciences, Anhui University of Chinese Medicine, Hefei 230071, China
- Publication Type:Research Article
- Keywords:
plant natural product;
post-modification enzyme;
biosynthetic pathway;
synthetic biology
- From:
Acta Pharmaceutica Sinica
2021;56(12):3285-3299
- CountryChina
- Language:Chinese
-
Abstract:
Plant natural products (PNPs) are important sources of innovative drugs. They are mainly obtained by isolation or extraction from plants. Low content and with structural analogues in plants result in high production cost, which restricts the research and application of PNPs. While biopathway construction by synthetic biology provides an alternative for production of PNPs. By biosynthetic pathway analysis of PNPs and reconstructing the biopathway in microorganisms, we can produce PNPs in cell factories efficiently. Recently, several predominantly international reports about biosynthesis of PNPs and its synthetic biology production, triggered the researches of PNPs. Abundant traditional Chinese medicine resources and profound cultural heritage of Chinese medicine make biosynthesis pathway analysis of PNPs to be a research hotspot. And some of the studies have achieved significant progress. Here, recent progress in the biosynthesis of plant natural products and its synthetic biology was reviewed. In particular, the application of new methods and technologies in recent years were summarized and discussed. This will provide reference for the biopathway construction of plant natural products.
