Research progress of febuxostat derivatives as xanthine oxidase inhibitors
10.16438/j.0513-4870.2021-1032
- VernacularTitle:黄嘌呤氧化酶抑制剂非布司他衍生物的研究进展
- Author:
Wen-ye LI
;
Na ZHAI
;
Xiu-lian JU
;
Gen-yan LIU
- Publication Type:Research Article
- Keywords:
xanthine oxidase;
inhibitor;
febuxostat;
gout;
structure-activity relationship
- From:
Acta Pharmaceutica Sinica
2021;56(12):3401-3413
- CountryChina
- Language:Chinese
-
Abstract:
Febuxostat, as a xanthine oxidase inhibitor, is a classic anti-gout drug with significant therapeutic effects and good tolerability. The structures of febuxostat and its derivatives can be divided into two parts: a substituted phenyl ring and a five-membered or six-membered heterocyclic ring with a carboxyl substitution. This paper reviewed the research progress of febuxostat derivatives in recent ten years and classified the structure-activity relationships of various febuxostat derivatives. Exploring the action mechanisms and structure-activity relationships of xanthine oxidase inhibitors might be significant for the rational design and development of new anti-gout chemical entities.
