Research progress of poly (β-amino ester)s-based gene vector
10.16438/j.0513-4870.2021-0653
- VernacularTitle:聚 (β-氨基酯) 基因载体的研究进展
- Author:
Ying-shi LIU
;
Hai-mei HU
- Publication Type:Research Article
- Keywords:
poly (β-amino ester);
polycation;
non-viral vector;
gene therapy;
gene delivery system
- From:
Acta Pharmaceutica Sinica
2021;56(12):3451-3459
- CountryChina
- Language:Chinese
-
Abstract:
Poly (β-amino ester)s (PβAEs) contain tertiary amine backbones and biodegradable ester bonds, making them highly biocompatible and pH-responsive. Meanwhile, originated from combinatorial libraries, PβAEs are simple to synthesize, easy to obtain raw materials and can be easily adapted to meet the different performance needs of gene carriers by adjusting the monomer type, monomer ratio and reaction time. Therefore, PβAEs are promising material for non-viral gene carriers. This paper provides a comprehensive overview of the properties and synthesis of PβAEs gene carriers and summarizes the progress of research on the gene delivery of each type of PβAEs.
