Current drug research on intestinal mucosal healing in inflammatory bowel disease based on macrophage regulation
10.16438/j.0513-4870.2021-0616
- VernacularTitle:基于巨噬细胞对肠黏膜愈合调控治疗炎症性肠病的药物研究现状
- Author:
Xin-ke DU
;
Qing-sen RAN
;
Li LIU
;
Qing YANG
;
Li-dong SUN
;
Yu-jie LI
;
Ying CHEN
;
Xiao-xin ZHU
;
Qi LI
- Publication Type:Research Article
- Keywords:
inflammatory bowel disease;
intestinal mucosal healing;
macrophage;
polarization balance;
healing through immune response
- From:
Acta Pharmaceutica Sinica
2021;56(12):3392-3400
- CountryChina
- Language:Chinese
-
Abstract:
Complete healing of the intestinal mucosa is the most ideal goal in the treatment of inflammatory bowel disease (IBD). The intestinal mucosa healing not only significantly alters the course of the disease and relieves clinical symptoms, but also markedly reduces the occurrence of complications and prevents recurrence of IBD. As chronic inflammation associated with peptic ulcer damage is the main pathological feature of IBD, clinical treatment is mainly based on anti-inflammatory therapy, but such therapy cannot promote the healing of the intestinal mucosa of patients. Therefore, how to achieve long-term remission of IBD is still an urgent challenge. In the process of intestinal mucosal repair, the polarization of macrophages maintains the homeostasis of the intestinal microenvironment, which is a representative process that promotes mucosal inflammatory-repair. It is a key part of initiating tissue regeneration that should not be underestimated. In this paper, we reviewed the literature of the past decade, focusing on the promotion of intestinal mucosal healing in IBD. The discussion will highlight the importance and feasibility of regulating macrophages to promote intestinal mucosal repair. Following this thought, we discuss the shortcomings of current clinical treatments and summarize the relevant drugs which have potential to promote intestinal mucosal repair. The aim is to provide effective potential drugs and therapeutic targets for the treatment of IBD.
