Research progress of metabotropic glutamate receptor 5 in related central nervous system diseases
10.11665/j.issn.1000-5048.20210614
- VernacularTitle:代谢型谷氨酸受体5在中枢神经系统疾病中的研究进展
- Author:
Enni ZHU
1
;
Chaoran WU
;
Hong LIAO
Author Information
1. 中国药科大学新药筛选中心
- Publication Type:Journal Article
- Keywords:
metabotropic glutamate receptor 5;
physiological function;
central nervous system diseases;
drug development;
advances
- From:
Journal of China Pharmaceutical University
2021;52(6):751-758
- CountryChina
- Language:English
-
Abstract:
As a key component of glutamatergic system, metabotropic glutamate receptor 5 (mGluR5) has been extensively involved in the regulation of physiological processes such as synaptic transmission, synaptic plasticity and synaptic excitation/inhibition balance.Over the past few decades, mGluR5 has been found to be closely related to multiple neurological and psychiatric disorders, thus it is of considerable interest as a drug target in the treatment of such disorders.This review summarizes the structure and distribution of mGluR5, its normal physiological function, its pathological roles in related central nervous system (CNS) diseases, as well as the current status of its drug development, in order to provide reference for further investigation.
