Effect and mechanism of muscle injury on liver lipid metabolism in Duchenne muscular dystrophy mice
10.11665/j.issn.1000-5048.20210612
- VernacularTitle:杜氏肌营养不良小鼠肌损伤对肝脏脂质代谢的影响及其作用机制
- Author:
Ziling ZHANG
1
;
Qian LU
;
Dengqiu XU
;
Qinwei YU
;
Zhenzhou JIANG
Author Information
1. 中国药科大学新药筛选中心
- Publication Type:Journal Article
- Keywords:
Duchene muscular dystrophy;
skeletal muscle injury;
liver lipid accumulation;
lipid synthesis
- From:
Journal of China Pharmaceutical University
2021;52(6):735-741
- CountryChina
- Language:Chinese
-
Abstract:
Duchene muscular dystrophy (DMD) is a serious progressive muscular dystrophy.Reports in recent years about abnormal lipid in DMD patients have increased, yet little attention has been paid to liver lipid.This study aimed to explore the effect of dystrophin gene defect on liver lipid synthesis.7-week-old mdx male mice were used as DMD model.The conditions of liver function, liver lipid accumulation and liver lipid synthesis were determined through liver tissue morphological examination, blood biochemical examination, and detection of hepatic gene and protein expression.The results showed that lipid droplets in liver of mdx mice increased significantly.The contents of total cholesterol and triglyceride in liver, aspartate aminotransferase and alanine aminotransferase in serum increased.The gene and protein expression of hepatic lipid synthesis-related enzymes such as fatty acid synthase, acetyl CoA carboxylase, and sterol regulatory element binding protein 1-c were up-regulated.These results showed accumulation of liver lipid in 7-week-old mdx male mice.
