Progress of intelligent-responsive insulin delivery mediated by glucose oxidase
10.11665/j.issn.1000-5048.20210603
- VernacularTitle:葡萄糖氧化酶介导的智能响应胰岛素递送的研究进展
- Author:
Jingru YANG
1
;
Yuhong MA
;
Dechun HUANG
;
Hongliang QIAN
;
Wei CHEN
Author Information
1. 中国药科大学工学院制药工程教研室
- Publication Type:Journal Article
- Keywords:
glucose oxidase;
glucose response;
insulin delivery;
diabetes treatment;
advances
- From:
Journal of China Pharmaceutical University
2021;52(6):663-674
- CountryChina
- Language:Chinese
-
Abstract:
The delivery of exogenous insulin is very important for the treatment of type 1 and advanced type 2 diabetes.Traditional injectable administration is prone to cause hypoglycemia, while the intelligent insulin system has the advantages of safety, long-term effectiveness, and high responsiveness.Glucose oxidase (GOx) can consume O2 and catalyze glucose to produce gluconic acid and H2O2.Therefore, the O2 level, H2O2 content and pH of GOx system are closely related to the glucose level in the system.This review introduces the application of GOx in closed-loop insulin delivery systems at home and abroad in recent years, which can be divided into single response and multiple response of pH-response, hypoxia-response, and H2O2-response according to the mechanism.It also discusses the opportunities and challenge facing by the application of GOx in the future.
