Research progress of mono-(ADP-ribosyl) transferase family and their inhibitors in tumor therapy

VernacularTitle:单-ADP核糖转移酶家族及其抑制剂在肿瘤治疗中的研究进展
Author: Yin LI ¹ ; Hongfeng GU ; Yi ZOU ; Shuping WANG ; Yungen XU
Author Information

1. 中国药科大学药物化学系
Publication Type:Journal Article
Keywords: ADP-ribosylation; MARTs; MARTs inhibitor; tumor therapy; advances
From: Journal of China Pharmaceutical University 2021;52(6):643-652
CountryChina
Language:Chinese
Abstract: Poly-adenosine diphosphate ribose polymerases (PARPs) play an important role in DNA repair and apoptosis.Among them, mono-(ADP-ribosyl) transferase (MARTs) can regulate various cell reactions by catalyzing and transferring single ADP-ribose.Most MARTs are highly expressed in cancers, which is closely related to the occurrence and progression of cancers.This review introduces the MARTs that are highly expressed in cancers, classifies them according to the differences of their structural domains, and reviews their known mechanism, their close relationship with cancers, their potential value in cancer therapy and the research progress of corresponding inhibitors.These targets are expected to provide new research ideas for cancer therapy in the era of precision medicine.