Preventive effect of HARRT combined with SMZ-TMP on opportunistic infection in AIDS patients
10.3969/j.issn.1006-2483.2021.06.025
- VernacularTitle:HARRT联合复方新诺明对艾滋病患者机会性感染的预防作用
- Author:
Xumin MIAO
1
,
2
;
Qingqing LIU
1
,
2
Author Information
1. Department of Pharmacy，Nantong Third People'
2. s Hospital，Nantong , Jiangsu 226006 , China
- Publication Type:Journal Article
- Keywords:
HIV/AIDS;
Highly effective antiretroviral therapy (HARRT);
SMZ-TMP;
Opportunistic infections (OIs);
Preventive effect
- From:
Journal of Public Health and Preventive Medicine
2021;32(6):103-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of highly effective antiretroviral therapy (HARRT) combined with SMZ-TMP on opportunistic infection (OIs) in patients with HIV/AIDS. Methods The 6-month follow-up data of 170 AIDS patients in the Department of Infectious Diseases of Nantong Third People's Hospital were analyzed retrospectively. All patients received HARRT. According to whether SMZ-TMP was used for OIs preventive treatment, the patients were divided into a prevention group (n=47) and a non-prevention group (n=123). The demographic data such as gender, age, occupation and education level of the two groups were collected. The incidence of OIs in the 12-month follow-up period of the two groups was analyzed and compared, and the single factor unconditional logistic regression analysis and multi factor unconditional logistic regression analysis were carried out for AIDS patients taking SMZ-TMP. Results The proportion of prophylactic use of SMZ-TMP in 170 AIDS patients was only 27.65%, and the incidence of OIs in the prevention group was 31.91%, which was significantly lower than that in the non-prevention group (57.72%) (χ2=9.062, P<0.05). Among the 15 patients with OIs in the prevention group, the proportion of patients with one, two to three and more than three types of OIs accounted for 64.71%, 23.53% and 4.26%, respectively, while those in the non prevention group were 30.99%, 38.03% and 30.98%, respectively. There was a significant difference in the composition ratio between the two groups (χ2=7.419, P<0.05). The incidences of bacterial pneumonia, tuberculosis, extrapulmonary tuberculosis, PCP and fungal stomatitis in the prevention group were 18.89%, 10.64%, 4.26%, 6.38% and 4.26%, respectively, which were significantly lower than those in the non-prevention group (30.89%, 25.20%, 16.26%, 18.70% and 18.70%, respectively) (χ2=4.473, 4.322, 4.350, 3.982, 5.656, P<0.05). Univariate and multivariate unconditional logistic regression analysis showed that the benefits of SMZ-TMP, doctors' detailed recommendation of SMZ-TMP and higher education level were all influencing factors (95% CI: 135.79-3748.36, 107.43-2954.67, 1.873-25.94). Conclusion Prophylactic use of SMZ-TMP significantly reduced the incidence of AIDS related OIs, but the proportion of SMZ-TMP use was relatively low. It is necessary to take relevant measures according to the influencing factors of taking SMZ-TMP to improve the use rate of SMZ-TMP in AIDS patients.
