The changes and influencing factors of CD4+ T cell numbers during different periods of antiviral therapy in HIV/AIDS patients in Yichang City
10.3969/j.issn.1006-2483.2021.06.021
- VernacularTitle:宜昌市HIV/AIDS抗病毒治疗前后CD4+T淋巴细胞变化及影响因素
- Author:
Wen LEI
1
;
Jianhua LIU
1
;
Huiqi ZHANG
1
;
Hao ZHANG
1
;
Yi YANG
2
;
Fangfang LU
1
;
Yu TIAN
1
;
Jie MIN
1
;
Fangfang LI
1
;
Hongping CHEN
1
Author Information
1. Yichang Centers for Disease Control and Prevention , Yichang , Hubei 444300 , China
2. Zhijiang Centers for Disease Control and Prevention , Yichang , Hubei 443299, China
- Publication Type:Journal Article
- Keywords:
HIV/AIDS;
HARRT;
CD4+ T cell
- From:
Journal of Public Health and Preventive Medicine
2021;32(6):88-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the changes of CD4+ T cell numbers at different periods of antiviral therapy in HIV-infected and AIDS patients (HIV/AIDS) in Yichang City. Methods The relevant information was retrieved from the National AIDS Comprehensive Prevention Information System-Antiretroviral Treatment Management Database. Changes in the number of CD4+ T cells were analyzed in HIV/AIDS patients who started receiving highly active antiretroviral therapy (HAART) and continued the treatment for 3 years from January 1, 2003 to December 31, 2017 in Yichang. Results The number of CD4+T lymphocytes in 550 HIV/AIDS cases increased significantly at various time points within 3 years after treatment, and increased with the increase of treatment time（F=100.20，P<0.001）. The CD4+T cell counts of different baseline level groups were statistically different before and after treatment（F=8.57，P<0.01）. The CD4+ T cell counts of patients who started treatment at age of 15-30 years old increased faster than those who started treatment at age of over 30 years old（F=1.27，P<0.05）. Conclusion HAART has a significant effect on the increase of CD4+T cells, and the early treatment is more effective. Early detection, diagnosis and treatment should be promoted, and anti-viral treatment should be actively carried out.
