Research Progress of Role of Autophagy in Rheumatoid Arthritis and Traditional Chinese Medicine Intervention
10.13422/j.cnki.syfjx.20210343
- VernacularTitle:自噬在类风湿关节炎中的作用及中药干预研究进展
- Author:
Ni-xue ZHANG
1
;
Xiao-hui SU
1
;
Ya-ge TIAN
1
;
Na LIN
1
;
Xiang-ying KONG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences， Beijing 100700，China
- Publication Type:Research Article
- Keywords:
rheumatoid arthritis;
autophagy;
synovial arthritis;
bone destruction;
pannus;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(6):169-175
- CountryChina
- Language:Chinese
-
Abstract:
For rheumatoid arthritis， glucocorticoids or immunosuppressive agents are currently used in clinical treatment， but long-term use of these drugs has large side effect on humans， and immunosuppressive agents are expensive. To a certain extent， its wide application is limited. The treatment of rheumatoid arthritis with traditional Chinese medicine（TCM） has a long history and little toxic and side effect， but its specific mechanism of action needs further exploration. The process of autophagy is an active biological process in which cells themselves are stimulated by the outside world through intracellular signal transduction to maintain a stable internal environment. Its abnormality is involved in the occurrence of many diseases. At present， studies have shown that abnormal autophagy is closely related to the occurrence and development of rheumatoid arthritis， which can interfere with the pathological changes of RA pannus formation， synovial inflammation and bone destruction and affect the disease process. In recent years， many studies have found that traditional Chinese medicine and its active ingredients can affect the pathological development of rheumatoid arthritis by regulating autophagy. This article investigates the relevant literature on the intervention of rheumatoid arthritis by regulating autophagy through using TCM， with a view to providing new ideas for basic research， new drug development and clinical treatment of rheumatoid arthritis.
