Efficacy and Mechanism of Qingre Lishi Prescription in Treating Children with Acute Bacterial Lower Urinary Tract Infection of Bladder Damp-heat Syndrome
10.13422/j.cnki.syfjx.20210724
- VernacularTitle:清热利湿方治疗小儿急性细菌性下尿路感染膀胱湿热证的疗效及机制
- Author:
Xin-yao ZHANG
1
;
Jian LIU
2
;
Ning JI
1
;
Jin-hua FENG
2
;
Wan-qi WANG
1
;
Kai JIANG
2
Author Information
1. Changchun University of Chinese Medicine，Changchun 130117，China
2. Affiliated Hospital of Changchun University of Chinese Medicine，Changchun 130021，China
- Publication Type:Research Article
- Keywords:
Qingre Lishi prescription;
children with urinary tract infection;
bladder damp-heat syndrome;
inflammatory factor;
bacteria;
immune function;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(10):51-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of Qingre Lishi prescription in treating children with acute bacterial lower urinary tract infection of bladder damp-heat syndrome， and to explore its mechanism of action. Method:Eighty children with acute bacterial lower urinary tract infection of late bladder damp-heat syndrome who were admitted to the Affiliated Hospital of Changchun University of Chinese Medicine were divided into control group and observation group， 40 cases in each group. Patients in control group were given Bazhengsan for oral treatment on basis of basic treatment， while patients in observation group were given Qingre Lishi prescription for oral administration plus external washing treatment. After two weeks of treatment， the clinical and etiological effect， traditional Chinese medicine （TCM） syndrome scores， antipyretic time and urinary negative time， adverse reactions， and urine pathogens （Escherichia coli， Enterococcus faecalis， Strange proteus， Klebsiella pneumoniae）， serum inflammatory factor indicators ［tumor necrosis factor-α （TNF-α）， interleukin-6 （IL-6）， interleukin-8 （IL-8）， calcium lowering PCT， white blood cell count （WBC） and serum C-reactive protein （CRP）］， immune function indicators ［T cell subsets （CD3+， CD4+， CD8+） and complement （C3， C4）］ were comapred between two groups. Result:The clinical efficacy of observation group was 92.50% （37/40）， which was significantly higher than 65.00% （26/40） in control group （χ2=9.038， P<0.01）， the etiological efficacy of observation group was 87.50% （35/40）， which was significantly higher than 60.00% （24/40） in control group （χ2=7.813， P<0.01）. After treatment， the scores of TCM syndromes of the two groups were significantly reduced （P<0.05）. The scores of fever， frequent urination， urgent urination， painful urination， difficulty urinating and abdominal pain in two groups were significantly lower than those before treatment （P<0.05）， and the TCM syndrome scores in observation group were lower than those in control group （P<0.05）， the antipyretic time and urinary bacteria turning negative time of observation group were significantly lower than those in control group （P<0.05）， the Escherichia coli， Enterococcus faecalis， Proteus mirabilis， Klebsiella pneumoniae pathogenic bacteria detected in both groups were both significantly lower than those before treatment （P<0.05）. After treatment， the levels of inflammatory factors such as TNF-α， IL-6， IL-8， PCT， WBC and CRP in two groups were significantly lower than those before treatment （P<0.05）， the immune function of the two groups was significantly improved， and the levels of CD3+， CD4+， C3， and C4 in observation group were higher than those in control group（P<0.05）， and the CD8+ level was lower than that in control group （P<0.05）. The incidence of adverse reactions had no significant difference between two groups. Conclusion:Qingre Lishi prescription has good clinical effect in treating children with acute bacterial lower urinary tract infection with bladder damp-heat syndrome. It can improve TCM syndromes and clinical symptoms. Its mechanism is related to inhibiting pathogenic bacteria， reducing inflammation， and improving immune function， and it has good security.
