Generic Association Analysis on "Prescription-Formula-Dosage-Property" of Tibetan Medicine Based on Partial Order Structure and Property Theory
10.13422/j.cnki.syfjx.20210515
- VernacularTitle:基于偏序结构和药性理论的“方-药-量-性”共性关联分析
- Author:
Dang-zhi WENCHENG
1
;
Wang-jia RENZHEN
2
;
Zha-xi GAZANG
1
;
Duo-jie GERI
3
;
Nan-jia CAIRANG
1
;
Jia YU
2
;
Cai-dan REZENG
1
Author Information
1. College of Pharmacy，Qinghai Nationalities University，Xining 810007，China
2. School of Ethnic Medicine，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
3. Huangnan Tibetan Hospital，Xining 811300，China
- Publication Type:Research Article
- Keywords:
Tibetan medicine;
Ro-nus-zhu-rjes;
partially ordered structure;
prescription-formula-dosage-property;
relevance research
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(9):184-192
- CountryChina
- Language:Chinese
-
Abstract:
Objective:In view of the complexity of the "Prescription-Formula-Dosage-Property" relationship of Tibetan medicine and the outstanding common relationship，it is difficult to reveal the hidden and specific rules of clinical medication of Tibetan medicine. Method:Based on the attribute partial order structure and the vector structure model of "Ro-Nus-Zhu-Rjes"（Taste，Post-Digestive Tastes and Potency），clustering analysis and other methods and software，this study analyzed the "Prescription-Formula-Dosage-Property" relationship of 184 commonly used prescriptions in the 1995 edition of the standards issued by the Ministry of Tibetan medicine（SIMTM）. Result:Among them，the analysis of the relationship between prescription and formula found that 11 prescriptions with the largest common attribute，such as Chebulae Fructus and Carthami Flos，were the key components of classification and compatibility，which could effectively classify the 8 kinds of prescriptions for the treatment of lung disease，tripa disease and blood fever. Among them，the san Yin and auxiliary viscera function prescriptions，such as Sanguotang powder and Liuwei Liangyao powder，had the strongest commonality. According to the analysis of relationship between formula and dosage ，the dosage of Chebulae Fructus，Carthami Flos，pomegranate seed，Phyllanthi Fructus was the highest，which suggested that these drugs were often used as primary drugs，while the Liuwei Liangyao powder，such as Amomi Fructus Rotundus and Tsaoko Fructus，had a higher frequency but a lower dose，which mainly played a role in regulating the overall drug property of the prescription and protecting the viscera. The Tibetan medicine-specific drugs including Moschus，Bovis Calculus，and Zhaxun，which were used in a high frequency but very low dose，had the effect of enhancing the drug property and guiding the affected part. According to the analysis of the relationship between dosage and property，there were many prescriptions belonging to cool nature，accounting for 75.6%. It was found that 67 prescriptions did not conform to the efficacy due to their different dosage. Conclusion:There are many common components and common usages in Tibetan medicine prescriptions. If these common associations are not treated，it will lead to the result that all diseases take these common associations as the core，but the hidden key factors cannot be solved. Therefore，it is necessary to pay attention to sensitivity and specificity at the multi-dimensional level of "prescription-formula-dosage-property"，so as to reveal the clinical medication thought of Tibetan medicine more effectively.
