Animal Model of Cystitis Based on Clinical Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20211003
- VernacularTitle:基于中西医临床病症特点的膀胱炎动物模型分析
- Author:
Yi-xuan XIE
1
;
Sai WANG
1
;
Hao-zhe LIU
1
;
Fei-peng ZHU
1
;
Ming-san MIAO
1
Author Information
1. Henan University of traditional Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
cystitis;
clinical characteristics of traditional Chinese and western medicine;
animal models
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(11):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Cystitis， one of the most common diseases in the urinary system， is manifested by urinary frequency， urinary urgency， and bladder pain， which are known as the classic symptom triad of bladder irritation， especially in women. In recent years， with the change of the lifestyle， the prevalence of bladder diseases in China is increasing year by year. According to the characteristics of etiology， pathogenesis， and clinical symptoms of cystitis， this paper listed the clinical diagnostic criteria in traditional Chinese medicine （TCM） and western medicine after consulting the relevant literature. Through the analysis of the existing animal model of cystitis， the fit between the model and clinical manifestations was evaluated， and the advantages and disadvantages were summarized. The models induced by "intraperitoneal injection of cyclophosphamide" and "Freund's complete adjuvant combined with bladder catheterization" were proved highly matched with manifestations despite some shortcomings such as long time and high cost. At present， the diagnostic criteria of cystitis are mainly based on western medicine， and the definitive diagnosis of the relevant types still depends on cystoscopy and tissue biopsy. The lack of TCM syndrome model limits the TCM research. Additionally， four diagnostic methods in TCM cannot be well applied to animal models because of the susceptibility to subjective factors. Behavioral tests can be used to determine the model index and develop the relevant behavior rating scale. Therefore， it is necessary to establish an animal model of cystitis in line with the clinical characteristics of western medicine and TCM syndrome differentiation， so as to better promote the study of cystitis.
