Efficacy of Chinese Medicinal Formulae for Antimicrobial-resistant Pneumonia: A Systematic Review and Meta-analysis
10.13422/j.cnki.syfjx.20210613
- VernacularTitle:中药方剂内服治疗耐药细菌性肺炎的系统评价与Meta分析
- Author:
Li-yang JIA
1
;
Dong DENG
1
;
Yao QU
1
;
Li-hua SUN
1
;
Jian-hong BU
2
;
Zhen-yi CHEN
3
;
Miao-qing YE
4
;
Bang-jiang FANG
1
Author Information
1. Longhua Hospital， Shanghai University of Traditional Chinese Medicine （TCM），Shanghai 200032， China
2. Shanghai Municipal Hospital of TCM，Shanghai 200071， China
3. Henan Province Hospital of TCM，Zhengzhou 450002，China
4. Shanxi Province Hospital of TCM，Xi'an 710000，China
- Publication Type:Research Article
- Keywords:
Chinese medicinal formulae;
antimicrobial-resistant pneumonia;
systematic review;
Meta-analysis;
randomized controlled trials （RCTs）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(11):205-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of Chinese medicinal formulae in the treatment of antimicrobial-resistant pneumonia. Method:Following article retrieval from eight databases and data extraction by two reviewers， the methodological quality of the included trials was assessed and the outcome indicators were subjected to Meta-analysis using RevMan 5.3. Result:A total of 24 randomized controlled trials （RCTs） were included， involving 1 818 cases. Meta-analysis showed that Chinese medicinal formulae combined with western routine intervention was superior to the western routine intervention in improving the overall response rate （ORR） ［relative risk （RR）=1.27， 95% confidence interval （CI） （1.21， 1.34）， P
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<0.000 01］， the bacterial clearance rate ［RR=1.49，95% CI （1.33， 1.66）， P![]()
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<0.000 01］， and the clinical pulmonary infection score （CPIS） ［mean difference （MD）=-1.64， 95% CI （-1.87， -1.41）， P![]()
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<0.000 01］. There was no significant difference in the incidence of adverse reactions ［RR=0.72， 95% CI （0.48， 1.07）， P![]()
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=0.1］. The comparison with the western routine intervention also revealed that Chinese medicinal formulae better improved the ORR and CPIS. Conclusion:According to the current research results， the Chinese medicinal formulae alone or combined with western routine intervention yielded more favorable clinical outcomes than western routine intervention in the treatment of antimicrobial-resistant pneumonia， without increasing the incidence of adverse events. Due to limited quality and quantity of the included RCTs， more high-quality trials are required to verify the above conclusions.
