Effect of Modified Shiquan Dabutang on Inflammatory and Bone Metabolism Indexes in Elderly Patients with Osteoporotic Intertrochanteric Fractures Due to Qi and Blood Deficiency
10.13422/j.cnki.syfjx.20211194
- VernacularTitle:十全大补汤加减对高龄骨质疏松性股骨粗隆间骨折气血两虚型患者炎症及骨代谢指标的影响
- Author:
Xiong-wei DENG
1
;
Hai-lang LE
1
;
De-wang CHEN
1
;
He-jun HU
1
Author Information
1. Hongdu Traditional Chinese Medcine（TCM） Hospital Affiliated to Jiangxi University of TCM， Nanchang 330006， China
- Publication Type:Research Article
- Keywords:
modified Shiquan Dabutang;
elderly patients;
osteoporotic intertrochanteric fractures;
Qi and blood deficiency syndrome;
pain mediators;
inflammatory factors;
bone metabolism indexes
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(11):123-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of modified Shiquan Dabutang in the treatment of elderly patients with osteoporotic intertrochanteric fractures （OIFs） due to Qi and blood deficiency by observing its impacts on inflammatory and bone metabolism indexes. Method:Ninety-eight elderly patients admitted to our hospital for OIFs of Qi and blood deficiency syndrome from April 2018 to April 2020 were randomized into an observation group （n=49） and a control group （n=49）. Following the proximal femoral nail antirotation （PFNA） fixation， patients in the control group were treated with Guipiwan， while those in the observation group received the modified Shiquan Dabutang. The clinical efficacy， inflammatory and bone metabolism indexes， and complications were compared between the two groups after four weeks of treatment. Result:The levels of such serum indexes as fibroblast growth factor-2 （FGF-2）， osteoprotegerin （OPG）， transforming growth factor-β1 （TGF-β1）， β-endorphin （β-EP）， bone-specific alkaline phosphatase （BALP）， and osteocalcin （BGP） in the observation group after treatment were significantly elevated as compared with those in the control group （P<0.05）， whereas the serum tumor necrosis factor-α （TNF-α） and D-dimer （D-D） declined （P<0.05）. The TCM symptom score in the observation group after treatment was obviously lower than that in the control group， while the Harris Hip Score （HHS） was higher （P<0.05）. The overall response rate of the observation group was 93.88% （46/49）， higher than 75.51% （37/49） of the control group （χ2=6.376， P<0.05）. The total incidence of incision infection， deep vein thrombosis of lower limbs， and pulmonary infection in the control group was 24.49% （12/49）， significantly higher than 6.12% （3/49） in the observation group （χ2=6.607， P<0.05）. Conclusion:The modified Shiquan Dabutang is able to alleviate inflammation， regulate bone metabolism， promote bone repair， and reduce the incidence of complications in elderly patients with OIFs due to Qi and blood deficiency.
