Correlates of Metabolic Abnormalities in Bipolar I Disorder at Initiation of Acute Phase Treatment.
- Author:
Byungsu KIM
1
;
Sangeok KIM
;
Roger S MCINTYRE
;
Hui Joon PARK
;
Seong Yoon KIM
;
Yeon Ho JOO
Author Information
1. Department of Psychiatry and Health Promotion Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
Hypercholesterolemia;
Hyperglycemia;
Obesity
- MeSH:
Bipolar Disorder;
Body Mass Index;
Cholesterol;
Cohort Studies;
Disease Management;
Dyslipidemias;
Fasting;
Glucose;
Humans;
Hypercholesterolemia;
Hyperglycemia;
Male;
Obesity;
Plasma;
Prevalence
- From:Psychiatry Investigation
2009;6(2):78-84
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Treatment of bipolar patients is often complicated by metabolic abnormalities such as obesity, diabetes, and dyslipidemia. We therefore evaluated the prevalence of these abnormalities and their correlates, in bipolar I patients, at the time of commencement of pharmacological treatment for acute mood episodes. METHODS: The study cohort consisted of 184 bipolar I patients hospitalized for treatment of acute mood episodes. Socio-demographic and clinical variables were noted and metabolic parameters, including body mass index, fasting plasma glucose, fasting total cholesterol, and current treatment(s) for diabetes and/or dyslipidemia were measured before initiating medication(s). RESULTS: Fifty-six (30.4%) subjects met our criteria for obesity; 80 (43.5%) had hyperglycemia, with 8 (4.3%) receiving anti-diabetic medication; and 38 (20.7%) had hypercholesterolemia, with 2 (1.1%) receiving cholesterol-lowering agents. We found that male sex (chi-square=5.359, p=0.021), depressed or mixed state versus manic state (chi-square=4.302, p=0.038), and duration of illness (t=2.756, p=0.006) were significantly associated with obesity. Older age (t=3.668, p<0.001), later age of disease onset (t=2.271, p=0.024), and lower level of educational attainment (beta=-0.531, p=0.001) were associated with hyperglycemia. CONCLUSION: Our finding that metabolic abnormalities are prevalent when initiating acute pharmacological treatment in bipolar I patients indicates that these factors should be integrated into treatment plans at the onset of disease management.
