AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia.
- Author:
Eun Jeong JOO
1
;
Kyu Young LEE
;
Seong Hoon JEONG
;
Myoung Sun ROH
;
Se Hyun KIM
;
Yong Min AHN
;
Yong Sik KIM
Author Information
1. Department of Psychiatry, Eulji University School of Medicine, Daegeon, Korea.
- Publication Type:Original Article
- Keywords:
AKT1 gene;
Association;
Lewis scale;
Obstetric complication;
Schizophrenia
- MeSH:
Age of Onset;
Alleles;
Diagnostic and Statistical Manual of Mental Disorders;
Female;
Genetic Association Studies;
Genotype;
Haplotypes;
Humans;
Male;
Mothers;
Oncogenes;
Polymorphism, Single Nucleotide;
Retrospective Studies;
Schizophrenia;
Thymoma
- From:Psychiatry Investigation
2009;6(2):102-107
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: We performed a genetic association study with schizophrenic patients to investigate whether the V-akt murine thymoma viral oncogene homolog 1 (AKT1) gene plays a role in obstetric complications. METHODS: One-hundred-eighty patients with schizophrenia (male, 113; female, 67) were included. All patients fulfilled DSM-IV criteria for schizophrenia. Obstetric complications were measured by the Lewis scale. Prenatal and perinatal information was retrospectively collected from the patients' mothers. We selected six single nucleotide polymorphisms (SNPs) for the AKT1 gene: SNP1 (rs3803300), SNP2 (rs1130214), SNP3 (rs3730358), SNP4 (rs 1130233), SNP5 (rs2494732), and SNPA (rs2498804). The genotype data were analyzed for an association with the Lewis total score in terms of allele, genotype, and haplotype distribution. RESULTS: The mean total Lewis scores were 1.30+/-1.61 for males and 1.54+/-1.87 for females. Higher total score tended to be correlated with an earlier age of onset of schizophrenia in females. In the total sample, no SNP was associated with obstetric complications. However, the additional analyses for male and female subgroups found a significant association between SNPA and SNP4 and Lewis score in females (p=0.02 for SNPA, p=0.04 for SNP4). The SNP5-SNPA haplotype showed a positive association with obstetric complications (p=0.03) in the female patient group. CONCLUSION: We found an association between SNPs in the AKT1 gene and total Lewis score measuring obstetric complications in female patients with schizophrenia. Because these findings did not survive a correction for multiple testing, the significance should be interpreted carefully and replication studies are required.
