Psoriasis-related Signaling Pathways Regulated by Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20211595
- VernacularTitle:中医药调控银屑病相关信号通路研究进展
- Author:
Shuang CAO
1
;
Yan-yan ZHOU
1
;
Jing-dong YAN
2
Author Information
1. Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine （TCM）;
psoriasis;
signaling pathway;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(15):243-250
- CountryChina
- Language:Chinese
-
Abstract:
As an inflammatory skin disease with a gradually increasing prevalence，psoriasis has negatively impacted the quality of life of patients and has attracted widespread attention from the medical community. The pathogenesis of psoriasis can be affected by a variety of genetic，environmental， and immune factors，and cytokine-driven epidermal proliferation，abnormal differentiation，inflammation， and neovascularization contribute to the pathogenesis，involving the interaction between immune and skin cells. However， some pathogenesis is still a blind spot for research，which brings great challenges to clinical treatment. Therefore， the identification of effective targets for psoriasis is critical in the research on psoriasis. Signaling pathways， another hotpot in the research on psoriasis， play an important cellular transduction role in the pathological mechanism of psoriasis and serve as key transduction factors regulating the immune and inflammatory responses to psoriasis. With the in-depth research in the field of network pharmacology and molecular biology， single Chinese medicine and Chinese medicinal compound can exert a therapeutic role by regulating multiple signaling pathways related to psoriasis. In recent years，traditional Chinese medicine （TCM） has achieved good clinical efficacy in the prevention and treatment of psoriasis，such as relieving pruritus，decreasing the area of skin lesions，improving anxiety， and preventing complications， which confirms the credibility of TCM in the understanding and treatment of psoriasis. Despite the rich theoretical and clinical research on the prevention and treatment of psoriasis，studies on the regulation of psoriasis-related signaling pathways and mechanisms of action by TCM are rarely reported. Therefore，the present study reviewed the available research in recent years and introduced the following six major signaling pathways related to psoriasis which are regulated by TCM： Janus kinase（JAK）/signal transducer and activator of transcription（STAT） signaling pathway，mitogen-activated protein kinase（MAPK） signaling pathway，phosphatidylinositol-3-kinases（PI3K）/protein kinase B（Akt） signaling pathway，nuclear transcription factor-κB（NF-κB） signaling pathway，Wnt signaling pathway， and Notch signaling pathway.
