Research Progress on Pharmacological Mechanism of Danhong Injection in Treatment of Cardiovascular and Cerebrovascular Diseases
10.13422/j.cnki.syfjx.20210349
- VernacularTitle:丹红注射液治疗心脑血管疾病的药理作用机制研究进展
- Author:
Yin-ying CHEN
1
;
Hua LI
2
;
Ping WU
1
;
Zhong WANG
3
;
Jie WANG
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
2. Dongfang Hospital，Beijing University of Chinese Medicine，Beijing 100078，China
3. Institute of Basic Research in Clinical Medicine， China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Research Article
- Keywords:
Danhong injection;
cardiovascular and cerebrovascular diseases;
pharmacological effect;
multiple pathways;
multiple targets;
chemical composition;
coronary heart disease
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(15):188-196
- CountryChina
- Language:Chinese
-
Abstract:
Cardiovascular and cerebrovascular diseases are one of the major diseases endangering human health， and its morbidity and mortality are still in the rising stage in our country. Traditional Chinese medicine （TCM） injections play an important role in the prevention and treatment of cardiovascular and cerebrovascular diseases due to their advantages of rapid onset， remarkable curative effect， and convenient use. Among them， Danhong injection （DHI）， a Chinese medicine injection for promoting blood circulation and removing blood stasis， is widely used in the clinical treatment of cardio-cerebrovascular diseases. DHI is composed of Salviae Miltiorrhizae Radix et Rhizoma （Danshen in Chinese） and Carthami Flos （Honghua in Chinese）， and mainly contains phenolic acids， tanshinones and flavonoids. A large number of studies have shown that DHI has a significant effect in the treatment of ischemic cardio-cerebrovascular diseases， is a representative drug of co-therapy of brain and heart of TCM， its pharmacological effects related to many aspects such as anti-inflammatory， anti-oxidation， anti-coagulation. At the same time， Other studies have also explained the protective effects of DHI on cardiovascular and cerebrovascular diseases through the overall regulation and intervention of multiple targets and pathways. However， DHI has a wide range of clinical applications， there are still many unknown pharmacological effects to be further explored. Therefore， this article summarizes the current researches on the chemical components of DHI， the multi-target and multi-path pharmacological mechanisms of DHI in the treatment of cardiovascular and cerebrovascular diseases， and introduces the latest pharmacological research progress， so as to provide theoretical guidance for clinical rational drug use and subsequent in-depth research.
