No Evidence for Association between Tyrosine Hydroxylase Gene Val81Met Polymorphism and Susceptibility to Tardive Dyskinesia in Schizophrenia.
- Author:
Heon Jeong LEE
1
;
Seung Gul KANG
;
Jung Eun CHOI
;
Young Min PARK
;
Se Won LIM
;
Min Kyu RHEE
;
Seung Hyun KIM
;
Leen KIM
Author Information
1. Department of Psychiatry, Korea University College of Medicine, Seoul, Korea. leen54@chol.com
- Publication Type:Original Article
- Keywords:
Tardive dyskinesia;
Tyrosine hydoxylase;
Polymorphism
- MeSH:
Dopamine;
Dyskinesias;
Gene Frequency;
Genotype;
Humans;
Movement Disorders;
Schizophrenia;
Tyrosine;
Tyrosine 3-Monooxygenase
- From:Psychiatry Investigation
2009;6(2):108-111
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in dopamine biosynthesis. Because the TH Val81Met polymorphism is located in the amino-terminal regulatory domain of the tetrameric enzyme, it is a candidate marker for susceptibility to dopamine-related traits. We investigated the hypothesis that TH Val81Met polymorphism can influence susceptibility to tardive dyskinesia (TD) in schizophrenia. METHODS: TH Val81Met polymorphism was analyzed by PCR-based methods in 83 schizophrenic patients with TD and 126 schizophrenic patients without TD, matched for antipsychotic drug exposure and other relevant variables. RESULTS: There was no significant association of the genotype and allele frequencies determined by the TH Val81Met polymorphism between TD and non-TD patients. In addition, there was no significant difference in terms of total Abnormal Involuntary Movement Scale scores among the three genotype groups. CONCLUSION: Within the limitations imposed by the size of the clinical sample, these findings suggest that the Val81Met polymorphism of the TH gene does not contribute significantly to the risk for TD.
