Effect of Modified Chaihu Shugansan on Gallbladder Function and Inflammatory Cytokines Levels in Treatment of Chronic Cholecystitis Cholelithiasis
10.13422/j.cnki.syfjx.20210331
- VernacularTitle:柴胡疏肝散加减治疗慢性胆囊炎胆石症及胆囊功能和炎症因子的影响
- Author:
Hai-fang CAO
1
;
Yu ZHANG
1
;
Sheng-tai WEI
1
;
Qiong LEI
1
;
De-long CAO
1
;
Qing-hua LU
1
Author Information
1. The Fourth People's Hospital of Qinghai Province，Xining 810001，China
- Publication Type:Research Article
- Keywords:
chronic cholecystitis;
cholelithiasis;
stagnation of liver and gallbladder Qi;
Chaihu Shugansan;
gallbladder contraction;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(15):63-67
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the clinical efficacy and influence of modified Chaihu Shugansan combined with ursodeoxycholic acid tablets on inflammatory factors in treatment of chronic cholecystitis cholelithiasis （stagnation of liver and gallbladder Qi）. Method:One hundred and ten patients were randomly divided into control group （60 cases） and observation group （60 cases）. Both groups received lifestyle intervention， and oral ursodeoxycholic acid tablets， 50 mg/time， taken in the morning and evening meals. Patients in control group additionally took Yidanshu capsules orally， 4 capsules/time， 3 times/day. Patients in observation group additionally took modified Chaihu Shugansan orally， 1 dose/day. The treatment courses continued 3 months in both groups. Before and after treatment， traditional Chinese medicine （TCM） symptom scores were graded， the ultrasound status of chronic gallbladder inflammation， gallbladder contraction function and stones was graded， the levels of interleukin-6 （IL-6）， IL-8， tumor necrosis factor-α （TNF-α） and nuclear transcription factor-κB（NF-κB）Were detected， and safety was evaluated. The efficacy for TCM syndromes， imaging efficacy and the efficacy for eliminating gallbladder stones were compared between the two groups. Result:The efficacy for TCM syndrome， efficacy on color ultrasound for chronic cholecystitis and the efficacy on imaging for cholelithiasis in the observation group were all better than those in the control group（Z=2.104，Z=2.076，Z=2.101，P<0.05）. The thickness of gallbladder wall and volume of the gallbladder of the observation group were smaller than those of the control group （P<0.01）， and gallbladder contraction function was higher than that in control group （P<0.01）. Levels of IL-6， IL-8， TNF-α and NF-κB in observation group were lower than those in control group （P<0.01）. Conclusion:modified Chaihu Shugansan combined with ursodeoxycholic acid in the treatment of chronic cholecystitis and cholelithiasis （liver and gall Qi stagnation） is better than Yidanshu capsule combined with ursodeoxycholic acid sour scheme in terms of clinical efficacy， imaging efficacy， and elimination of gallbladder stones. It can reduce inflammation， and enhance gallbladder contraction， with high safety in clinical use.
