Clinical Efficacy of Modified Qilang Prescription in Treatment of Drug-dependent Constipation with Qi and Yin Deficiency and Its Effect on MTL， VIP， 5-HT， and 5-HT4R in Peripheral Blood
10.13422/j.cnki.syfjx.20211593
- VernacularTitle:加味芪榔方治疗药物依赖性气阴两虚型便秘患者的疗效及对外周血MTL，VIP，5-HT和5-HT4R的影响
- Author:
Zhe SHI
1
;
Meng-en ZHOU
1
;
Ke-hui ZHANG
1
;
Meng-xing CAO
1
;
Yong LI
1
Author Information
1. Shanghai Municipal Hospital of Traditional Chinese Medicine（TCM），Shanghai University of TCM， Shanghai 200071， China
- Publication Type:Research Article
- Keywords:
modified Qilang prescription;
lactulose;
drug-dependent constipation;
Chinese medicine treatment;
vasoactive intestinal peptide （VIP）;
motilin （MTL）;
5-hydroxytryptamine （5-HT）;
5-hydroxytryptamine 4 receptor （5-HT4R）
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(15):51-56
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the curative efficacy of modified Qilang prescription on drug-dependent constipation with Qi and Yin deficiency and the effects on serum vasoactive intestinal peptide （VIP）， motilin （MTL）， 5-hydroxytryptamine （5-HT）， and 5-hydroxytryptamine 4 receptor （5-HT4R）. Method:A total of 160 patients diagnosed with drug-dependent constipation were randomly divided into a treatment group （n=80， Qilang prescription） and a control group （n=80， lactulose oral solution）. The treatment lasted for eight weeks. Changes in clinical symptoms， traditional Chinese medicine （TCM） syndrome， and serum VIP， MTL， 5-HT， and 5-HT4R before and after treatment were observed. The clinical efficacies of the two groups were compared. An eight-week follow-up was carried out for the observation of recurrent rate and TCM syndrome. Result:The overall response rate of the treatment group （90.91%） was higher than that （75.00%） of the control group （Z=-6.514，P<0.05）. There was no significant difference in serum VIP， MTL， 5-HT， and 5-HT4R between the two groups before treatment. After treatment for eight weeks， both groups showed reduced serum VIP level as compared with those before treatment， and the treatment group was inferior to the control group （P<0.05）. The serum MTL levels of the two groups were both higher than those before treatment （P<0.05）， and the treatment group was superior to the control group （P<0.05）. After treatment， the level of 5-HT in the treatment group was higher than that in the control group （P<0.05）. The post-treatment 5-HT4R level in the treatment group slightly increased （P<0.05）， but no significant difference in 5-HT4R levels between the two groups after treatment was observed. During the eight-week follow-up， the recurrence rate in the treatment group was significantly lower than that in the control group at the 2nd and 4th weeks （P<0.05）. There was no significant difference in the recurrence rate between the treatment group ［57.14% （40/70）］ and the control group ［64.81% （35/54）］ after eight weeks. Conclusion:Modified Qilang prescription was superior to lactulose in the short- and mid-term efficacy on drug-dependent constipation with Qi and Yin deficiency. No significant difference in the long-term efficacy was observed. The underlying therapeutic mechanism might be related to the regulation of serum VIP， MTL， 5-HT， and 5-HT4R levels.
