Advances on Chemical Constituents of Essential Oils from Perillae Folium and Their Pharmacological Effect：A Review
10.13422/j.cnki.syfjx.20211205
- VernacularTitle:紫苏叶挥发油化学成分及其药理作用研究进展
- Author:
Ping ZHONG
1
;
Zhen-chao WANG
1
;
Ying-meng LIU
1
;
Ping WANG
1
;
Wen OU
1
;
Ming YANG
1
;
Hai-yan ZHANG
1
Author Information
1. Key Laboratory of Modern Preparation of Traditional Chinese Medicine （TCM），Ministry of Education，Jiangxi University of Chinese Medicine，Nanchang 330004，China
- Publication Type:Research Article
- Keywords:
volatile oils from Perillae Folium;
extraction process;
chemical constituents;
pharmacological activities;
research advances
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(13):215-225
- CountryChina
- Language:Chinese
-
Abstract:
Perilla frutescens is a traditional medicinal and edible plant widely distributed in China and enjoys an extensive usage. P. frutescens contains multiple essential oils， which are composed of monoterpenes， sesquiterpenes， and their oxygen-containing derivatives. Compared with other parts of P. frutescens， Perillae Folium produce more oils， with volatile oils as the main constituents. There are many active substances in the volatile oils from Perillae Folium， mainly including perillaldehyde， perillaketone， perillaalcohol， D-limonene， β-caryophylene， etc. Such factors as germplasm， growth environment， extraction method， cultivation time， and harvest period all can trigger changes in volatile oil constituents and content from Perillae Folium. The volatile oils from Perillae Folium have diverse pharmacological effects like anti-oxidation， anti-bacteria， anti-inflammation， vasodilation， anti-tumor， and anti-depression， implying its high clinical application value. However， the chemical constituents in volatile oils from Perillae Folium are complex and unstable and their pharmacological activities are affected by many factors， so the safety and effectiveness of clinical medication fail to be guaranteed， which may has impeded the rational and effective use of these volatile oils. Many scholars in China and abroad have conducted a lot of research on the volatile oils from Perillae Folium， but there is currently no systematic and comprehensive research report on the chemical constituents of volatile oils from Perillae Folium and their pharmacological effects. This paper reviewed the relevant domestic and foreign literature， analyzed the development status of volatile oils from Perillae Folium， and summarized their extraction process， chemical constituents， and pharmacological actions， aiming to provide a reference for their further development， clinical application， and risk assessment.
