Experimental Research Progress of Replenishing Qi and Activating Blood Circulation Traditional Chinese Medicine on Mitochondrial Quality Control in Treatment of Chronic Heart Failure
10.13422/j.cnki.syfjx.20210312
- VernacularTitle:益气活血类中药干预线粒体质量控制治疗心力衰竭的实验研究进展
- Author:
Ran XIA
1
;
Jing WANG
1
;
Xiao-hua DAI
2
;
Yong-lei ZENG
3
;
Qing-ling LI
1
;
Qiang MA
1
;
Bing GAO
1
;
Wei WANG
1
;
Yi WANG
1
Author Information
1. Graduate School，Key Laboratory of Xin'an Medicine，Ministry of Education， Anhui University of Chinese Medicine，Hefei 230038，China
2. The First Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230031，China
3. The Second Affiliated Hospital of Anhui University of Chinese Medicine，Hefei 230061，China
- Publication Type:Research Article
- Keywords:
replenishing Qi and activating blood circulation;
heart failure;
mitochondrial;
intervention
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(5):206-213
- CountryChina
- Language:Chinese
-
Abstract:
Heart failure is a complex clinical syndrome，which is the final result of compensatory failure of heart injury caused by various reasons. Long-term persistent cardiac stress leads to mitochondrial dysfunction，which in turn further damages cardiomyocytes and leads to disease progression. Timely removal of damaged mitochondria in cardiomyocytes and maintaining a good living environment of viable mitochondria is not only an effective means to protect cardiomyocytes，but also a new way to prevent and treat heart failure and ventricular remodeling. Mitochondrial quality control is a series of cellular activities for mitochondria to maintain their structural and functional stability，including oxidative stress response，regulation of mitochondrial dynamics，mitochondrial autophagy，intracellular calcium regulation and so on. Traditional Chinese medicine（TCM） mostly uses drugs of replenishing Qi and activating blood circulation in the treatment of chronic heart failure，and Qi and mitochondria are similar in function. According to TCM，the performance of the body as "static，descending and inhibitory" in the case of Qi deficiency can also be compared with the energy defect of mitochondria. The classical method of tonifying qi and activating blood circulation in TCM can be applied here. In recent years，TCM takes mitochondria as the target and carries out many related experimental studies from the point of view of myocardial energy supply. It is found that Chinese herbs for replenishing Qi and activating blood circulation can participate in regulating the quality control mechanism of intracellular mitochondria with multiple targets and links. It is proved by experiments that Chinese herbs for replenishing Qi and activating blood circulation can exert myocardial protective effect through this mechanism.
