Factors Affecting the Recurrence of Hepatocellular Carcinoma after Surgical Resection.
- Author:
Hyoung Won CHO
1
;
Jae Gil LEE
;
Chi Young LIM
;
Chang Moo KANG
;
Kyung Sik KIM
;
Jin Sub CHOI
;
Woo Jung LEE
;
Byong Ro KIM
Author Information
1. Department of Surgery, Yonsei University College of Medicine, Seoul, Korea. choi5491@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Hepatocellular Carcinoma;
Recurrence;
Risk factors
- MeSH:
Carcinoma, Hepatocellular*;
Disease-Free Survival;
Early Diagnosis;
Female;
Hepatitis B e Antigens;
Hepatitis B Surface Antigens;
Humans;
Incidence;
Indocyanine Green;
Logic;
Male;
Multivariate Analysis;
Prognosis;
Recurrence*;
Retrospective Studies;
Risk Factors;
Survival Rate
- From:Journal of the Korean Surgical Society
2005;69(6):465-470
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The prognosis of advanced hepatocellular carcinoma (HCC) is very grave. The most effective method to improve the survival rate of HCC patients is early diagnosis and curative resection. The aim of this study is to investigate risk factors affecting the recurrence of HCC after curative resection. METHOD: We retrospectively analyzed 287 HCC patients who underwent surgical resection at Severence Hospital between Jan. 1998 and Dec. 2003. They consisted of 222 males and 65 females whose median age was 52 years. RESULTS: Overall survival rates of 1, 3 and 5 year were 91, 71 and 64%, respectively, and overall disease free survival rates of 1, 3 and 5 year were 68, 48 and 29%, respectively. In univariate analysis, HBeAg, HBsAg, indocyanine green retention rate at 15 minutes (ICG-R15), microvascular invasion, tumor number, tumor size, satellite nodule, pathologic T stage (pT stage) and preoperative transarterial chemoembolization (TACE) were factors affecting the recurrence of primary HCC after curative resection. In multivariate analysis, HBeAg was the most important factor for recurrence and tumor size also had statistical significance. CONCLUSION: We concluded that knowledge of risk factors for postoperative recurrence provides a basis for logical approaches to prevention. The long-term prognosis after resection of HCC remains unsatisfactory as a result of a high incidence of recurrence. Prevention and effective treatment of recurrence are the most important strategies to improve the long-term survival results of HCC. And prospective studies about antiviral therapy for HBV are required to prevent recurrence of HCC.
