Review on Mechanism of Multi-target Intervention of Traditional Chinese Medicine on Metabolic Syndrome
10.13422/j.cnki.syfjx.20210339
- VernacularTitle:中医药多靶点干预代谢综合征机制研究概述
- Author:
Li LIU
1
;
Wei-zhong LI
1
;
Shi-han WANG
2
;
Guo-liang ZOU
1
;
Yan-bo SUI
1
;
Juan JIN
1
;
Xiao-xue WANG
1
;
Fan WU
1
;
De-hui FAN
1
;
Yu-bo HAN
1
Author Information
1. Heilongjiang University of Chinese Medicine， Harbin 150040， China
2. Guang'anmen Hospital， China Academy of Chinese Medical Sciences， Beijing 100053， China
- Publication Type:Research Article
- Keywords:
metabolic syndrome;
pathogenesis;
insulin resistance;
central obesity;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(3):214-221
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of metabolic syndrome （MS） includes insulin resistance （IR）， central obesity， chronic low-grade inflammation， oxidative stress， endoplasmic reticulum stress， elevated free fatty acid levels， intestinal flora imbalance， renin angiotensin system abnormality， and autophagy activity deficiency， etc. Most researchers believe that IR plays a central role in the pathogenesis of MS， and abdominal obesity is an important initial factor of MS. According to the incidence and clinical characteristics， MS is classified as "obesity" "pidan" " abdominal fullness " and other diseases. It is said that the pathogenesis of MS is related to the deficiency of spleen and kidney， the formation of phlegm， turbidity， blood stasis and other pathological products， which damage the body's functions of qi， blood， yin and yang. Traditional Chinese medicine （TCM） has unique advantages in treating MS based on the holistic view and syndrome differentiation concept. It has multi-level， multi-target and multi-channel treatment characteristics. It can intervene insulin signal transduction， regulate adipocyte factor secretion level， relieve oxidative stress and endoplasmic reticulum stress response， regulate intestinal flora and renin angiotensin system， reduce free fatty acid level and regulation Autophagy and other ways to improve chronic low-grade inflammation and IR status， and then comprehensive prevention and treatment of MS and its complications. However， the following problems still exist：lack of high-quality randomized controlled clinical research and large sample real-world research， clinical unified diagnosis and treatment standard has not yet formed， lack of genetic animal model in basic research， relatively single signal pathway and target of experimental research， and difficulty in timely formation of clinical transformation of scientific research achievements. Therefore， we should make full use of modern scientific and technological means to carry out systematic and standardized multicenter， large sample， high-quality randomized controlled trials or real-world research， we should prepare perfect animal models， focus on the crosstalk relationship between multiple related cell signaling pathways， and actively explore the potential relationship between signaling pathways and prescription compatibility， so as to actively promote basic scientific research achievements Clinical practice may be the key research direction in the prevention and treatment of MS in TCM.
