Meta-analysis on Clinical Effect and Safety of Tanreqing Injection in Treatment of Elderly Chronic Bronchitis
10.13422/j.cnki.syfjx.20202211
- VernacularTitle:痰热清注射液治疗老年慢性支气管炎临床效果及安全性的Meta分析
- Author:
Jia-hao MO
1
;
Rui-lan HUANG
2
;
Qian WU
2
;
Ling-li GUO
2
;
Xiang-jun QI
2
;
Jin-sheng LI
3
;
Fu-ping XU
4
Author Information
1. The Second Clinical Medical College of Guangzhou University of Chinese Medicine，Guangzhou 510405，China
2. The First Clinical Medical College of Guangzhou University of Chinese Medicine， Guangzhou 510405，China
3. The Third Clinical Medical College of Guangzhou University of Chinese Medicine，Guangzhou 510405，China
4. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine，Pre-treatment Center of Guangdong Traditional Chinese MedicineHospital，Guangzhou 510120，China
- Publication Type:Research Article
- Keywords:
Tanreqing injection;
chronic bronchitis in the elderly;
Meta-analysis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(3):184-190
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the clinical efficacy of Tanreqing injection in the treatment of elderly chronic bronchitis. Method:CBM，CNKI，WanFang Data，VIP，PubMed，The Cochrane Library，Embase and other databases were retrieved by computer to screen out randomized controlled trials of Tanreqing injection in the treatment of elderly chronic bronchitis. The retrieval time was from the establishment to December 2019. After two researchers independently screened out the literatures according to the inclusion and exclusion criteria，extracted data and evaluated the literature quality，made meta-analysis using RevMan 5.3 software，and performed Egger test by Stata 14.0 software to evaluate publication bias. In case of any publication bias，clipping and supplementation method was further used to evaluate the effect of bias on the results. Result:A total of 48 studies were included，including 4 356 patients with diabetic nephropathy. The results of Meta-analysis showed that compared with conventional antibiotic therapy，the group of combination with Tanreqing injection was better than the control group in effective rate and lowering serum c-reactive protein （CRP） level，with statistically significant differences. The results of the publication bias test showed that a developmental bias in the effective rate. Further analysis based on the non-parametric clipping and supplementation method showed stable results of meta-analysis and no impact from potential publication bias. The adverse reactions had no statistically significance. Conclusion:This study shows that Tanreqing injection has a significant effect in treating chronic bronchitis in the elderly，and can reduce the serum CRP level of the patients. Compared with the conventional therapy group，the incidence of adverse reactions is not significantly increased，and the results need further clinical tests.
