Analysis on Animal Models of Thromboembolic Vasculitis Based on Clinical Symptoms in Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20210504
- VernacularTitle:基于中西医临床病症特点血栓闭塞性脉管炎动物模型分析
- Author:
Sai WANG
1
;
Ming BAI
1
;
Ming-san MIAO
1
Author Information
1. School of Pharmacy， Henan University of Traditional Chinese Medicine， Zhengzhou 450046， China
- Publication Type:Research Article
- Keywords:
thromboangiitis obliterans （TAO）;
gangrene;
animal model;
combination of disease and syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(8):235-240
- CountryChina
- Language:Chinese
-
Abstract:
Based on the clinical characteristics of thromboembolic vasculitis， the diagnostic criteria in western medicine and the dialectical standard in traditional Chinese medicine （TCM） were analyzed and established by consulting relevant literature， and the modeling method， modeling objects as well as modeling advantages and disadvantages for the animal models of thromboembolic vasculitis were summarized in this paper. By analyzing its coincidence with the characteristics of clinical symptoms in traditional Chinese and western medicine， it was found that the animal model of thromboembolic vasculitis had a higher degree of coincidence with the clinical symptoms in western medicine， as well as cold and dampness blocking collaterals syndrome and heat toxin injury yin syndrome in TCM， but lower degree of coincidence with damp-heat toxin syndrome and Qi-blood deficiency syndrome. There is no animal model consistent with blood stasis syndrome. The pathological and hemorheological indexes （blood viscosity， erythrocyte sedimentation rate） were the most common indexes. Compared with a large number of cases reported in clinical treatment of thromboangiitis obliterans， the experimental research was relatively weak. It is the focus of future research to establish a reasonable model to judge the quantitative standard， and to establish the animal model with higher coincidence degree with TCM syndrome.
