Research on Screening Method of Clinical Core Prescriptions of Traditional Chinese Medicine Based on Distance Clustering and Pseudo-Bic Criteria
10.13422/j.cnki.syfjx.20210311
- VernacularTitle:基于距离聚类结合伪BIC准则研究中医临床核心处方的筛选方法
- Author:
Ying WANG
1
;
Xiao-ran ZHANG
2
;
Jun-hong WANG
3
;
Xiang-zhong FANG
4
;
Xin-xin REN
3
;
Dong BAI
1
Author Information
1. Basic Medical School，Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. School of Science，Yanshan University，Qinhuangdao 066004，China
3. Dongzhimen Hospital of Beijing University of Chinese Medicine，Beijing 100700，China
4. School of Mathematical Sciences，Peking University，Beijing 100871，China
- Publication Type:Research Article
- Keywords:
clinical prescription of traditional Chinese medicine;
core prescription;
methodology;
inheritance of experience
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(8):179-187
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Based on the holistic view of traditional Chinese medicine（TCM） and the characteristics of syndrome differentiation and treatment，methods of distance clustering and distance clustering combined with pseudo-bit clear（BIC） criteria are adopted in this study to simulate the doctor's clinical prescription process，and excavate a clinician's core prescription for the treatment of a specific disease. Method:In this study， it was believed that the clinical prescriptions of TCM can be divided into the core prescription for the treatment of the main syndrome and the addition and subtraction part of the medication for the concurrent syndrome. The hospital information system （HIS）was used to export the medical records of specific diseases，and then the methods of distance clustering and distance clustering combined with pseudo-BIC criteria were adopted to analyze professor WANG Jun-hong's 103 prescriptions for the treatment of Qi and Yin deficiency type of attention deficit hyperactivity disorder（ADHD）. The core prescriptions were screened by finding the optimal balance between the number of herbs and the proportion of population using the herbs. Result:Test4 consisted of 15 herbs such as Acori Tatarinowii Rhizoma，Crataegi Fructus，Lycii Fructus，Gall1 Gigerii Endothelium Corneum，and Pseudostellariae Radix were selected as the core prescription. In analysis by TCM theory and confirmation by professor WANG Jun-hong， it was proved to meet the characteristics of TCM treatment for ADHD. Conclusion:Combination of distance clustering with pseudo-BIC criteria method can effectively sort and screen the core clinical prescriptions of TCM，and compared with the current core prescription screening methods，it is characterized by conforming to the doctor's clinical prescription process. This research is helpful to provide certain support for inheriting the experience from famous TCM doctors and for the development of new Chinese medicines.
