Neuronal Autophagy in Depression and Regulatory Effect of Traditional Chinese Medicine： A Review
10.13422/j.cnki.syfjx.20211502
- VernacularTitle:抑郁症神经元自噬机制及中医药调节作用研究进展
- Author:
Yan LIU
1
;
Jun LIU
1
;
Yao-song WU
1
;
Yu-long CHEN
1
;
Shan-shan REN
1
;
Yi-wan SHANG
1
;
Qian-wen HE
1
;
Ya-zhou SANG
1
Author Information
1. Henan Provincial Key Laboratory of Traditional Chinese Medicine Syndrome and Prescription in Signal Transduction，Academy of Chinese Medical Sciences， Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Research Article
- Keywords:
depression;
neuronal autophagy;
pathogenesis;
therapeutic mechanism;
traditional Chinese medicine （TCM） treatment
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(16):218-226
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a mental illness characterized by persistent negative feelings， which has seriously threatened people's health. In recent years， neuronal autophagy， an important stress response， has also been regarded as a hypothesis for the pathogenesis of depression. Relevant studies have shown that either insufficient or excessive autophagy triggers neuronal damage， and activated or inhibited neuronal autophagy can be observed in animal models of depression. Therefore， neuronal autophagy may be a double-edged sword involved in the pathogenesis of depression. It is believed in traditional Chinese medicine （TCM） that the occurrence of this disease is closely related to liver depression and spleen deficiency. Chinese medicine regulates the neuronal autophagy via multiple ways. The TCM monomers that regulate neuron autophagy are capable of protecting nerves or penetrating the blood-brain barrier. TCM compounds designed for soothing liver or invigorating spleen have been proved effective against this disease， demonstrating that the core pathogenesis of depression lies in liver depression and spleen deficiency. The regulatory effects of TCM on neuronal autophagy in depression models might result from its action on multiple targets， multiple pathways， and multiple systems. This paper discussed the limitations in current research based on the involvement of neuronal autophagy in depression and its treatments， in order to provide ideas for later similar research and that concerning TCM treatment of depression.
