Effect and Safety of Modified Buzhong Yiqitang on VEGF， IGF-1， TGF-β1， and Immune Function in Postoperative Patients with Non-small Cell Lung Cancer After Chemotherapy
10.13422/j.cnki.syfjx.20211013
- VernacularTitle:补中益气汤加减对非小细胞肺癌术后化疗患者VEGF，IGF-1，TGF-β1，免疫功能的影响及安全性分析
- Author:
Wen LUO
1
;
Tao WANG
1
;
Guo-jiang XIONG
2
;
Zong-wu LI
1
;
Chao QIAN
1
;
Chun-yin YANG
1
;
Guo-yan FAN
1
;
Zi-liang RUAN
1
;
Xiao-wen YU
1
;
Rui WANG
1
Author Information
1. Kunming Municipal Hospital of Traditional Chinese Medicine（TCM），Kunming 650504，China
2. Affiliated Hospital of Jiangxi University of TCM，Nanchang 330006，China
- Publication Type:Research Article
- Keywords:
Buzhong Yiqitang;
postoperative non-small cell lung cancer;
GP regimen （gemcitabine + cis-platinum）;
neovascularization;
tumor metastasis;
lung function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(16):90-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of modified Buzhong Yiqitang （BZYQT） in the treatment of postoperative patients with non-small cell lung cancer （Qi deficiency in lung and spleen） after chemotherapy， and to observe its effect on tumor angiogenesis， immune function， tumor indicators， and lung function indicators. Method:Ninety-six patients who were treated in the Kunming municipal hospital of traditional Chinese medicine from March 2018 to February 2020 due to postoperative chemotherapy for non-small cell lung cancer were selected and assigned into a control group （n=48， western medicine） and an observation group （n=48， western medicine+modified BZYQT） by the random number table. The curative efficacies were compared after the treatment. Result:After treatment， the serum levels of carcinoembryonic antigen （CEA）， cytokeratin 19 fragment 21-1 （CYFRA21-1）， serum insulin-like growth factor-1 （IGF-1）， vascular endothelial growth factor （VEGF）， and transforming growth factor（TGF）-β1 in the observation group were lower than those in the control group （P<0.05）， while the serum CD4+/CD8+，CD4+ cells， immunoglobulin G （IgG） levels， forced expiratory volume in one second （FEV1），and FEV1/forced vital capacity （FVC） in the observation group were higher than those in the control group （P<0.05）. A significant difference was observed in the total response rate between the observation group ［56.25% （27/48）］ and the control group ［35.42% （17/48）］ （χ2＝4.191，P<0.05）. For adverse reactions，the incidence of bone marrow suppression（χ2＝4.002）， gastrointestinal reaction （χ2＝7.069），and hepatic and renal injury （χ2＝5.151） was lower in the observation group than in the control group （P<0.05）. Conclusion:For postoperative patients with non-small cell lung cancer （Qi deficiency in lung and spleen） after chemotherapy， western medicine combined with modified BZYQT could ameliorate immune function， promote pulmonary function recovery， improve clinical efficacy， and reduce the incidence of adverse reactions.
