Treatment of Sepsis with Chinese Medicine： A Review Based on NF-κB Signaling Pathway
10.13422/j.cnki.syfjx.20211994
- VernacularTitle:基于NF-κB信号通路探讨中医药治疗脓毒症的研究进展
- Author:
Chao HU
1
;
Ping ZHU
1
;
Miao JIANG
1
;
Qian ZHANG
2
;
Wen-xiu XU
2
;
Li-ping OUYANG
2
;
Xiao SHAO
3
;
Kang SHEN
1
;
Sai-long CHEN
1
Author Information
1. Nanjing University of Chinese Medicine，Nanjing 210000，China
2. Suzhou Hospital of Traditional Chinese Medicine，Suzhou 215000，China
3. Nantong Hospital of Traditional Chinese Medicine，Nantong 226000，China
- Publication Type:Research Article
- Keywords:
nuclear transcription factor-κB（NF-κB） signaling pathway;
traditional Chinese medicine;
sepsis;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):216-224
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis， a common critical disease in the intensive care unit（ICU）， features high morbidity and mortality. At present， it is mainly tackled with western medicine， which may trigger a series of problems like antibiotic resistance， adverse hormonal reactions， and high cost after a long-term use. Therefore， exploring new efficient， safe， and cheap drugs and treatment modes has become the focus of our research at this stage. By virtue of unique advantages including "the concept of holism and individualized treatment based on syndrome differentiation"， Chinese medicine has accumulated quite rich experience in the prevention and treatment of sepsis. In recent years， research on the regulation of Chinese medicine on nuclear transcription factor-κB（NF-κB） signaling pathway in sepsis has kept emerging. On this basis， this paper reviewed the etiology and pathogenesis of sepsis， syndrome differentiation and treatment， NF-κB signaling pathway， and its intervention with Chinese medicine. It has been found that some single Chinese herbs and their extracts， Chinese herbal compounds， and Chinese herbal injections effectively inhibit the expression of such inflammatory factors as NF-κB-mediated tumor necrosis factor-α（TNF-α）， interleukin-1（IL-1）， and IL-6 as well as the related proteins， reduce the systemic inflammatory response and organ injury， and improve the prognosis by regulating the activation of NF-κB signaling pathway and the immune function of macrophages. However， due to the limitations of objective conditions， some studies also have the problems of fuzzy pro-inflammatory anti-inflammatory balance mechanism， unclear pharmacokinetics and low drug safety evaluation， which need to be further studied and explored in order to provide a new theoretical basis and diagnosis and treatment thinking for the treatment of sepsis with traditional Chinese medicine.
