Research Progress of Targeted Drug Delivery Nanocarriers Through Blood-brain Barrier
10.13422/j.cnki.syfjx.20211151
- VernacularTitle:穿透血脑屏障靶向给药纳米载体的研究进展
- Author:
Xin-jian LI
1
;
Bing-bing ZHANG
1
;
Ze-min OU
1
;
Lin YAN
1
;
Yan-jing WANG
1
;
Yao ZHANG
1
;
Yan TONG
1
;
De-wen LIU
1
;
Jin-yu WANG
1
Author Information
1. Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences，Beijing 100700，China
- Publication Type:Research Article
- Keywords:
nano-preparations;
blood-brain barrier;
targeted drug delivery system;
carrier materials;
central nervous system （CNS）;
liposomes;
Chinese materia medica
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):206-215
- CountryChina
- Language:Chinese
-
Abstract:
The small size， moderate drug loading， and targeting properties of nano-preparations make them can be excellent delivery tools for drugs， genes or proteins crossing the cell or blood-brain barrier （BBB）. Currently， facilitating drug crossing BBB with innovative nano-drug delivery systems is considered as a strategic approach for the prevention， diagnosis and treatment of central nervous system （CNS） diseases. However， with the deepening of the research， the adverse reactions and toxicity of nanocarriers have gradually attracted the attention of researchers. Based on this， this paper summarized the situation of BBB-penetrating targeted nano-preparations at home and abroad in recent years from the perspective of classification of types and properties of nanocarriers， and analyzed the advantages and disadvantages of each carrier. The results showed that nano-preparations with active ingredients of traditional Chinese medicine （TCM） as carriers have become a promising way of cancer treatment， but the complexity and diversity of TCM components limited its application to a certain extent. Further studies should be strengthened to lay a foundation for the application and development of TCM nano-preparations in the field of CNS diseases.
