Effect of Modified Shengmaiyin on Children with Acute Lymphocyte Leukemia of Deficiency of Both Qi and Blood
10.13422/j.cnki.syfjx.20210631
- VernacularTitle:加味生脉饮辅助化疗对气血两虚证急性淋巴细胞白血病患儿的影响
- Author:
Na AN
1
;
Gu-ying ZHANG
1
;
Yi-le ZHAO
1
;
Li-hong CAO
2
;
Jing WANG
3
;
Xue ZHANG
4
;
Yu-li LIANG
1
Author Information
1. Hebei Children's Hospital，Shijiazhuang 050031，China
2. Hebei Hospital of Traditional Chinese Medicine，Shijiazhuang 050013，China
3. The First Hospital of Hebei Medical University，Shijiazhuang 050030，China
4. Affiliated Hospital of Hebei Engineering University，Handan 056002，China
- Publication Type:Research Article
- Keywords:
acute lymphocytic leukemia;
deficiency of both Qi and blood;
Shengmaiyin;
nutritional status;
fatigue;
immune function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):126-131
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the regulatory effect of modified Shengmaiyin adjuvant chemotherapy on the nutritional status and immune function of children with acute lymphocyte （ALL）. Method:One hundred children with ALL chemotherapy were randomly divided into observation group and control group. Both groups were given VDLD regimen as the induction therapy and CAM regimen as the early therapy. Control group was given Shengmaiyin orally， 10 mL/time， 3 times/day. Observation group was given modified Shengmaiyin orally， 1 does/day. The course of treatment for both groups was 3 months. Micro-nutrition assessment （MNA） was carried out before and after treatment， and serum total protein （TB）， albumin （ALB）， prealbumin （PAB）， T cell CD4+， CD8+， immunoglobulin G （IgG）， IgM， IgA levels were detected before and after treatment. The ratio of CD4+/CD8+ was calculated. The traditional Chinese medicine （TCM） syndrome before and after treatment and the piper fatigue scale （PFS-R） and universal core scale of children's quality of life （PedsQL） were scored. The changes of white blood cells （WBC）， red blood cells （RBC）， hemoglobin （Hb） and platelets （PLT） were evaluated before and after treatment. Result:The nutritional status of the observation group was better than that of the control group after treatment （Z=2.018， P<0.05）. The observed fatigue was lighter than that of the control group （Z=2.029， P<0.05）. The MNA score of the observation group was higher than that of the control group （P<0.01）. The scores of PFS-R and deficiency of both Qi and blood were lower than those of the control group （P<0.01）. The CD4+ levels and CD4+/CD8+ levels of TB， ALB and PAB in the observation group were higher than those in the control group （P<0.01）， while the CD8+ was lower than the control group （P<0.01）. The IgM and IgA levels in the observation group were higher than those in the control group （P<0.01）. The RBC， Hb and PLT levels of the observation group were higher than those of the control group （P<0.01）. Conclusion:Modified Shengmaiyin can be used as adjuvant therapy for children with ALL chemotherapy by improving nutritional status， immune function and immune balance， reducing clinical symptoms， promoting the recovery of hematopoietic system and improving the quality of life.
