Effect of Zhenzhu Tiaozhi Capsule on HbA1c in Patient with Type 2 Diabetes Mellitus： A Real-world Study
10.13422/j.cnki.syfjx.20211991
- VernacularTitle:贞术调脂胶囊对2型糖尿病HbA1c疗效的真实世界研究
- Author:
Miao-wen WU
1
;
Xiao-qiang HUANG
1
;
Hui-xia ZHAN
1
;
Jin YANG
2
;
Liu-fen PENG
2
;
Qian LIU
1
;
Ying-hua JIN
1
;
Ying-yu CHEN
1
;
Jun-jiao XU
1
;
Si-ying LI
1
;
Yuan-zhen MEI
1
;
Sheng-hua PIAO
1
;
Xiang-lu RONG
1
;
Jiao GUO
1
Author Information
1. Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine，Guangzhou 510006，China
2. School of Medical Information and Engineering，Guangdong Pharmaceutical University，Guangzhou 510006，China
- Publication Type:Research Article
- Keywords:
type 2 diabetes mellitus（T2DM）;
Zhenzhu Tiaozhi capsule;
real-world study;
propensity score matching（PSM）;
generalized estimation equation（GEE）;
clinical efficacy
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):110-117
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the long-term effect of Zhenzhu Tiaozhi capsule（FTZ） on hemoglobin A1c（HbA1c）in patients with type 2 diabetes mellitus （T2DM） based on real-world data. Method:T2DM patients who were provided with FTZ （FTZ group） and those receiving conventional hypoglycemic drugs （control group） were extracted from the hospital information system （HIS） of the First Affiliated Hospital of Guangdong Pharmaceutical University， followed by propensity score matching （PSM） for balancing the confounding factors between groups. With HbA1c as the efficacy evaluation index， the difference in efficacy between the two groups was compared using t-test and χ2 test. For repeated measurement data of the same patient， the difference in efficacy and the stability of FTZ against HbA1c were analyzed by generalized estimating equation （GEE）. The factors that might affect the efficacy of FTZ against HbA1c were subjected to multivariate linear regression analysis （MLRA）， and the subgroup analyses were then conducted after the stratification of relevant factors. Result:There were 46 patients included in the FTZ group and 1 208 patients in the control group. PSM yielded 42 pairs of samples with balanced covariates between groups. As revealed by one-year observation， ① HbA1c in the FTZ group after treatment was 6.51%±1.09%. No significant difference was observed either in pre- and post-treatment comparison in the FTZ group or in its comparison with the control group. At the same time， the HbA1c compliance rate in the FTZ group was 73.8% after treatment. No significant difference was observed either in pre- and post-treatment comparison in the FTZ group or in its comparison with the control group. ② The GEE results showed that the post-treatment HbA1c levels in the two groups were not significantly different from each other. Moreover， the HbA1c level remained stable over treatment time. ③ MLRA and subgroup analyses results demonstrated that FTZ was more effective in patients with high baseline HbA1c ［β=-0.530，95% confidence interval（CI） -0.850～-0.209，P<0.01］ or those who were complicated with hypertension （β=-0.918，95%CI -1.614～-0.222，P<0.05）. Conclusion:In the real world， FTZ is able to control the blood sugar， and its effect is similar to those of conventional hypoglycemic drugs. Besides， it is capable of stabilizing the blood sugar for a long time.
