Protective Effect of Huangqi Guizhi Wuwutang Combined with Shengmaiyin on Cardiac Function of Diabetic Cardiomyopathy
10.13422/j.cnki.syfjx.20210334
- VernacularTitle:黄芪桂枝五物汤合生脉饮治疗糖尿病心肌病心脏功能的临床疗效
- Author:
Yu-na WEI
1
;
Xue-mei MO
2
;
Qiang WANG
3
;
Nan QU
4
;
Run-fen ZHONG
4
;
Bin WEI
4
Author Information
1. Guangxi University of Traditional Chinese Medicine，Nanning 530024，China
2. Armed Police Guangxi Corps Hospital，Nanning 530002，China
3. Guangxi International Zhuang Medical Hospital， Nanning 530001，China
4. Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese Medicine，Nanning 530011，China
- Publication Type:Research Article
- Keywords:
diabetic cardiomyopathy;
Huangqi Guizhi Wuwutang;
Shengmaiyin;
myocardial fibrosis;
inflammatory factors;
heart function
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(19):104-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the protective effect of Huangqi Guizhi Wuwutang combined with Shengmaiyin on the heart function in patients with diabetic cardiomyopathy and explore its anti-myocardial fibrosis and anti-inflammatory effects. Method:The 96 patients were randomly divided into observation group （48 cases） and control group （48 cases）. Both groups were given comprehensive measures to control blood sugar， blood lipids， blood pressure and heart failure. Patients in control group took Tongmai Jiangtang capsule， 3 granules/time， 3 times/day. Patients in observation group took Huangqi Guizhi Wuwutang combined with modified Shengmaiyin， 1 dose/day. The treatment courses were three months in both groups. Left ventricular ejection fraction （LVEF）， early diastolic peak velocity E peak/late diastolic peak velocity A peak （E/A）， left ventricular end diastolic diameter （LVEDd） and cardiac output per stroke （SV） through echocardiography were recorded before and after therapy. Cardiac troponin-I （cTn I）， troponin T （cTn-T）， creatine kinase isoenzyme -MB （CK-MB）， lactate dehydrogenase （LDH）， transforming growth factor-β1 （TGF-β1） before and after treatment ， matrix metalloproteinase-2 （MMP-2）， insulin-like growth factor-1 （IGF-1）， interleukin-6 （IL-6）， IL-1， tumor necrosis factor-α （TNF-α）， N-terminal pro-B-type natriuretic peptide （NT-proBNP）， soluble ST2 （sST2） and galectin-3 （Gal-3） levels were detected. Symptom of cardiac insufficiency and traditional Chinese medicine （TCM） syndrome score were evaluated before and after treatment. Result:The LVEF and E/A data in observation group were higher than those in control group （P<0.01）. The levels of cTn-I， cTn-T， LDH and CK-MB in the observation group were lower than those in the control group （P<0.01）. After treatment， the levels of TGF-β1， MMP-2， IGF-1， IL-6， IL-1， TNF-α， NT-proBNP， sST2 and Gal-3 in the observation group decreased and were lower than those in the control group （P<0.01）. The clinical efficacy of the observation group was better than that of the control group （Z=1.974，P<0.05）. Conclusion:On the basis of conventional intervention of western medicine， Huangqi Guizhi Wuwutang combined with modified Shengmaiyin has anti-inflammatory and anti-myocardial fibrosis effects， with inhibitory effect on myocardial remodeling， and can reduce myocardial tissue damage to improve ventricular diastolic function and protect heart function. With such high clinical efficacy， it is worthy of clinical use.
