Research Progress on Animal Models of Menopausal Syndrome： A Review
10.13422/j.cnki.syfjx.20211836
- VernacularTitle:围绝经期综合征动物模型研究进展
- Author:
Dan-ni ZHOU
1
;
Ruo-nan WEI
1
;
Meng-jiao KANG
1
;
Jia CHEN
1
;
Lin-hua ZHAO
2
;
Wei ZHANG
1
Author Information
1. Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Guang'anmen Hospital ，China Academy of Chinese Medical Sciences，Beijing 100053，China
- Publication Type:Research Article
- Keywords:
pre-menopause;
climacteric syndrome;
menopausal syndrome;
post-menopause;
animal model
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(18):243-250
- CountryChina
- Language:Chinese
-
Abstract:
In order to explore the pathological mechanism of perimenopausal syndrome and seek prevention and treatment measures， it is necessary to establish animal models that similar to human perimenopausal syndrome， so as to provide reference for drug research， new drug development and clinical application. In this paper， the keywords of "perimenopausal period" "perimenopausal syndrome" "menopause" "menopausal syndrome""menopausal period" "menopausal syndrome" and "animal" were searched in China National Knowledge Infrastructure （CNKI）， Chongqing Weipu， China Biomedical Literature Database （CBM） and Pubmed. In addition， the selection of domestic peripheral menopausal syndrome model animals in recent years and the advantages and disadvantages of corresponding models were summarized. A total of 673 studies were identified， of which 61 were included in the analysis. The most common animal model of perimenopausal syndrome is castration model， while the immunodeficiency model is less used. With the aging of the population and the rapid increase of psychosocial stress， the incidence of perimenopausal syndrome is high. Therefore， it is particularly important to explore the mechanism of perimenopausal syndrome. According to the experimental purpose， experimental period， experimental technology and other factors， the selection of appropriate model animals and modeling methods is the key of the success of the experiment of perimenopausal syndrome.
