Mechanisms of Classical Prescriptions and Their Active Components in Immunosenescence Regulation： A Review
10.13422/j.cnki.syfjx.20211705
- VernacularTitle:经典名方及其有效成分调节免疫衰老的作用机制研究进展
- Author:
Yue TU
1
;
Guang-xia NI
1
;
Yi-gang WAN
2
;
Huang HUANG
3
;
Bu-hui LIU
4
;
Qi-jun FANG
5
;
Mei-zi WANG
5
;
Jia-xin CHEN
5
;
Liang YUE
1
;
Zi-lin LI
1
;
Fee-lan CHONG
6
Author Information
1. School of Acupuncture and Tuina，School of Health and Rehabilitation，Nanjing University of Chinese Medicine，Nanjing 210023，China
2. Nanjing Drum Tower Hospital，The Affiliated Hospital of Nanjing University Medical School，Nanjing 210008，China
3. School of International Classical Prescription，Nanjing University of Chinese Medicine，Nanjing 210023，China
4. Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210029，China
5. Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine，Nanjing 210008，China
6. School of Pharmacy，Management and Science University，Shah Alam 40100，Malaysia
- Publication Type:Research Article
- Keywords:
immunosenescence;
classical prescriptions;
immune cells;
mechanisms
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(18):190-197
- CountryChina
- Language:Chinese
-
Abstract:
As the body ages， the immune system will undergo a series of changes， which are termed "immunosenescence" and are embodied in immune cells. Previous studies have shown that the immune cells involved in the regulation of immunosenescence include intrinsic immune cells and adaptive immune cells. Intrinsic immune cells are neutrophils， monocytes/macrophages， myeloid-derived suppressor cells， dendritic cells， natural killer cells， etc.， and the underlying mechanisms involve the regulation of cell number， phagocytosis， chemotaxis， adhesion， the function of toll-like receptor （TLR）， antigen presentation， macrophage polarization， cytotoxicity， migration， etc. The adaptive immune cells include T-lymphocytes and B-lymphocytes， and the underlying mechanisms involve the regulation of cell development， proliferation， differentiation， cell number， telomerase activity， self-reactive antibodies， etc. Immunosenescence is the manifestation of aging in the human body and is also an important target for delaying aging by Chinese medicine and western medicine. In recent years， scholars have found some classical prescriptions and their active components （such as Dushentang and total saponins in Panax ginseng leaves， and Shengmaiyin and anwulignan and total saponins in P. ginseng stems and leaves） can regulate immunosenescence by targeting the immune cells and interfering with their molecular regulatory mechanisms. In addition， the mechanisms of the classical prescriptions in regulating immunosenescence are closely related to autophagy. The representative prescription embodying the therapeutic principles of resolving blood stasis and promoting regeneration， Dahuang Zhechongwan， can delay D-galactose-induced renal aging in mice， and its underlying mechanisms are related to the regulation of the number and activity of thymic immune cells and improvement of the protein expression of autophagy-related markers and inflammatory cytokines in the kidney. Therefore， exploring the effects of the classical prescriptions and their active components by targeting the mechanisms of immunosenescence will become a new direction for investigating and developing anti-aging drugs.
