Clinical Evaluation and Mechanism of Xuesusheng Granule for Patients with Cancer Related Fatigue
10.13422/j.cnki.syfjx.20210632
- VernacularTitle:血速升颗粒对癌因性疲乏患者的疗效评价及机制
- Author:
Pu-yang LI
1
;
Zeng-bin FU
1
;
Yue-niu LI
2
;
Jian-lun LIAN
1
Author Information
1. Hebei Province Hospital of Traditional Chinese Medicine（TCM），Shijiazhuang 050007，China
2. Hebei Jingxing County Hospital of TCM，Shijiazhuang 050300，China
- Publication Type:Research Article
- Keywords:
cancer related fatigue;
syndrome of deficiency of Qi and blood;
Xuesushen granule;
quality of life;
myelosuppression;
immune function;
inflammatory factors
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(17):118-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the clinical efficacy of Xuesusheng granule for cancer related fatigue （CRF） deficiency of both Qi and blood in clinical practice， and to investigate its effect on immune function and quality of life. Method:According to random number table method， 118 patients were divided into observation group （59 cases） and control group （59 cases）. Patients in control group got Ejiao Huangqi oral liquid， 10-20 mL/time， 2 times/day. Patients in observation group got Xuesusheng granule， 10 g/time， 3 times/day. The treatment was continued for 8 weeks in both groups. Before and after treatment， scores of cancer fatigue scale （CFS）， functional assessment of cancer therapy （FACT） and Qi and blood deficiency syndrome were graded， and degree of fatigue was discussed with brief fatigue inventory scale-Chinese （BFI-C）. Levels of white blood cell count （WBC）， neutrophil count （NEU）， platelet count （PLT）， red blood cell count （RBC）， and hemoglobin （Hb） were compared before and after treatment.T lymphocyte subsets of （CD3+， CD4+， CD8+） levels， natural killer （NK） cells， interleukin-1（IL-1）， IL-6， IL-8 and tumor necrosis factor -α （TNF -α） were also detected， and the safety was evaluated. Result:After treatment the scores of each factor in CFS scale and the total score of CFS in the observation group were lower than those in the control group （P<0.01）， and the degree of fatigue was lower than that in control group （Z=2.101， P<0.05）. The total score of FACT and the scores of four dimensions of physiology， society/family， emotion and function in the observation group were lower than those in the control group （P<0.01）. Levels of WBC， NEU， RBC and Hb in the observation group were higher than those in the control group （P<0.01）. Scores of BFI-C， deficiency of Qi and blood were lower than those in control group （P<0.01）. Levels of NK， CD3+， CD4+ and CD4+/CD8+ in the observation group were all higher than those in the control group （P<0.01）， while the IL-1， CD8+， IL-6， IL-8 and TNF-α levels in observation group were lower than those in the control group （P<0.01）. Not observed， there was no adverse reaction related to Xususheng granule. Conclusion:Xuesusheng granule can improve the symptoms of fatigue， reduce the degree of fatigue， improve the quality of life， reduce the degree of bone marrow suppression， improve immune function， and regulate immune inflammatory factors with high clinical efficacy in the use for patients with CRF and deficiency of Qi and blood.
