Regulatory Mechanism of Traditional Chinese Medicine in Mitochondrial Quality Control for Diabetic Cardiomyopathy： A Review
10.13422/j.cnki.syfjx.20211316
- VernacularTitle:中医药调控线粒体质量控制治疗糖尿病心肌病研究进展
- Author:
Mo CHEN
1
;
Ying-juan WEN
1
;
Huan ZHAO
1
;
Li-juan CHEN
1
;
Wu-ning TONG
1
Author Information
1. Shaanxi University of Chinese Medicine，Xianyang 712046，China
- Publication Type:Research Article
- Keywords:
diabetic cardiomyopathy;
mitochondrial quality control;
Chinese medicine;
treatment;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(21):242-250
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic cardiomyopathy occurs in diabetic patients and is different from hypertensive heart disease， coronary atherosclerotic heart disease， and other cardiac abnormalities. The main clinical symptoms are systolic and diastolic cardiac dysfunction， myocardial fibrosis， congestive heart failure， and angina pectoris. As one of the main complications of diabetes， its incidence and fatality rates have been on the rise year by year. However， modern medicine still fails to figure out its pathogenesis and no specific drug is available， which has seriously affected the survival and quality of life of patients. Cardiomyocytes contain a large number of mitochondria， which participate in cardiac energy metabolism and other biological activities and occupy an important position in the development of diabetic cardiomyopathy. Mitochondrial quality control mainly involves mitochondrial oxidative stress， mitochondrial dynamics， mitochondrial autophagy， and intracellular calcium regulation， which is an important condition for stabilizing the normal mitochondrial structure and exerting normal mitochondrial functions. In recent years， the efficacy of traditional Chinese medicine in intervening in mitochondrial quality control through multiple angles， pathways， and targets to affect the structure and function of myocardial mitochondria and significantly improve the clinical symptoms of patients with diabetic cardiomyopathy has attracted wide attention from scholars. Therefore， this paper reviewed the experimental studies and/or clinical observations concerning the treatment of diabetic cardiomyopathy with effective compounds of Chinese herbs and/or Chinese herbal compounds in the past ten years to further explain the pathogenesis of diabetic cardiomyopathy， clarify the regulatory mechanism of traditional Chinese medicine in mitochondrial quality control， and summarize the scientific connotations and shortcomings of traditional Chinese medicine in the treatment of diabetic cardiomyopathy， hoping to provide certain ideas and methods for further clinical application of traditional Chinese medicine in the treatment of diabetic cardiomyopathy.
