Quantitative Integration and Verification of Components and Target Clusters of Traditional Chinese Medicine Based on Supramolecular Qi Chromatography Theory
10.13422/j.cnki.syfjx.20211149
- VernacularTitle:基于超分子“气析”理论定量整合与验证中药成分及靶点群
- Author:
Hai-ying LI
1
;
Xue PAN
1
;
Min-cun WANG
1
;
Yan-zi ZHOU
1
;
Ding-fang CHEN
1
;
Yue-feng WU
1
;
Yi-qun ZHOU
1
;
Fu-yuan HE
1
Author Information
1. Laboratory of Supramolecular Mechanism and Mathematic-physics Chracterization for Traditional Chinese Medicine，Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Chinese Materia Medica， School of Pharmacy，Hunan University of Chinese Medicine，Changsha 410208，China
- Publication Type:Research Article
- Keywords:
chemical composition;
target clusters;
network pharmacology;
supramolecular Qi chromatography theory;
imprinted template;
supramolecular chemistry;
network dynamics
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(21):207-213
- CountryChina
- Language:Chinese
-
Abstract:
The application of modern scientific theories and technologies to explore the mechanism of Chinese medicine and its compounds is one of the key issues in realizing the modernization of traditional Chinese medicine （TCM） research. Chinese medicine and its compounds produce comprehensive pharmacodynamics through multiple components acting on multiple targets， the core of clarifying the mechanism is to solve the key scientific problems of static correlation and dynamic integration verification between the components and the target network topology. At present， the effective method to clarify the mechanism of Chinese medicine and its compounds is to statically correlate the topological network of in vitro components and targets through network pharmacology. Although there are also component-target verification studies， they often learn from research idea of single component-single target， it is urgent to establish a quantitative integration and overall verification method that conforms to the characteristics of TCM. According to supramolecular Qi chromatography theory of TCM， the microscopic mechanism of interaction between Chinese medicine and human body is actually the two supramolecular host and object groups （the active ingredient group of Chinese medicine and the target group of human body） based on imprinted template， which shows the macroscopic properties and pharmacodynamics. Based on this， the author proposes to use supramolecular Qi chromatography theory as the guidance， combined with supramolecular chemistry， network dynamics， quantitative pharmacology and other methods to quantitatively integrate and verify the compositions and the target groups with imprinted template as the core predicted by network pharmacology， looking for the optimal quality markers， greatly reducing the difficulty of multi-component-multi-target experimental verification of Chinese medicine and its compounds.
