Clinical Efficacy of Modified Heweitang in Treatment of Functional Dyspepsia Due to Liver-stomach Disharmony
10.13422/j.cnki.syfjx.20210834
- VernacularTitle:和胃汤加减治疗功能性消化不良肝胃不和证的临床观察
- Author:
Xiao-yue LI
1
;
Jun CHENG
1
;
Hui LI
1
;
Zhong-xian YU
2
;
Zhong-da JIN
2
Author Information
1. The First Affiliated Hospital of Kangda College of Nanjing Medical University，Lianyungang 222000，China
2. Affiliated Changshu Hospital，Soochow University，Changshu 215500，China
- Publication Type:Research Article
- Keywords:
functional dyspepsia;
Heweitang;
gastrointestinal hormones;
brain-gut peptides
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(22):113-118
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical efficacy and safety of modified Heweitang in the treatment of functional dyspepsia （FD） due to liver-stomach disharmony and its regulation of gastrointestinal hormones and brain-gut peptides. Method:One hundred and twenty-six eligible patients were randomized into a control group （62 cases） and an observation group （64 cases）. Patients in the observation group took the modified Heweitang granules with warm water 30 min after meals， 10 g/time， 3 times/day， while those in the control group took the corresponding placebo granules at the same dose in the same manner. The treatment in both groups lasted for four weeks. Before and after treatment， the four main symptoms including postprandial satiety， early satiety， upper abdominal pain， and upper abdominal burning sensation were scored， followed by the examination of gastric emptying （GE） and the scoring of the functional digestive disorders quality of life questionnaire （FDDQL）， 7-point global overall symptom scale （GOSS）， and liver-stomach disharmony syndrome. The cholecystokinin （CCK）， motilin （MTL）， gastrin （GAS）， serotonin （5-HT）， vasoactive intestinal peptide （VIP）， and substance P （SP） levels before and after treatment were detected， and then the safety was evaluated. Result:After treatment， the scores of the four main symptoms， GOSS， and liver-stomach disharmony syndrome in the observation group were lower than those in the control group （P<0.01）， while the GE rate and FDDQL scores in the observation group were higher （P<0.01）. The CCK， GAS， 5-HT， and VIP levels of the observation group declined as compared with those of the control group （P<0.01）， whereas the MTL and SP levels were elevated （P<0.01）. After treatment， the overall response rate in the observation group was （51/57）89.47%， higher than （15/56）26.79% in the control group （χ2=45.696， P<0.01）. No drug-related adverse reactions were found during the trial. Conclusion:The modified Heweitang is efficient and safe in relieving the main and related symptoms and traditional Chinese medicine （TCM） syndrome， regulating the secretion of gastrointestinal hormones and brain-gut peptides， promoting GE rate， and improving the quality of life of patients with FD due to liver-stomach disharmony.
