Mechanism of Chinese Medicine in Xingnao and Kaiqiao Against Cerebral Ischemia/Reperfusion Injury： A Review
10.13422/j.cnki.syfjx.20212405
- VernacularTitle:醒脑开窍中药治疗脑缺血再灌注损伤作用机制的研究进展
- Author:
Zhi-gang LU
1
;
Chang-ming YANG
1
;
Xiang-hui KONG
1
;
Zhi-yuan GAO
1
;
Tong-mei ZHANG
2
Author Information
1. The First People's Hospital of Jingmen Affiliated to Hubei Minzhu University，Jingmen 448000，China
2. Preclinical Medicine School Affiliated to Tongji Medical College of Huazhong University of Science and Technology，Wuhan 430011，China
- Publication Type:Research Article
- Keywords:
Chinese medicine in Xingnao and Kaiqiao;
cerebral ischemia/reperfusion injury（CIRI）;
neuroprotective effect;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(24):235-242
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral ischemia/reperfusion injury （CIRI） is a common feature and the main pathophysiological mechanism of ischemic stroke（IS）， which is caused by a blood reperfusion injury in ischemic brain tissues. It can aggravate brain tissue injury and cause irreversible brain damage， seriously affecting the quality of life or even the life of patients. Hence， we must find out the exact mechanism as well as the effective therapeutic drugs and targets for CIRI. The Chinese medicine effective in Xingnao （restoring consciousness） and Kaiqiao （opening orifices） has been widely used in the treatment of CIRI and serves as a classic therapy for IS. In recent years， scholars have conducted extensive and in-depth studies on the mechanism and therapeutic targets of Chinese medicine in Xingnao and Kaiqiao. They found that those drugs could interfere with a series of changes after IS and achieve the remarkable curative effect. This study summarized the effect and mechanism of Chinese medicine in Xingnao and Kaiqiao in the treatment of CIRI， including reducing the inflammatory response and oxidative stress， alleviating brain edema and the toxicity of excitatory amino acids， reducing cell apoptosis， promoting angiogenesis and neurovascular remodeling， and improving blood-brain barrier injury. It is expected to provide references to clarify the mechanism and important targets of those drugs in resisting CIRI and ideas for the in-depth investigation and application of brain protection of Chinese medicine in Xingnao and Kaiqiao.
