Clinical Observation of Effects of Modified Xiangsha Liujunzi Tang Application on Adverse Reaction of Moderately/Highly Emetogenic Chemotherapy for Gastrointestinal Tumors
10.13422/j.cnki.syfjx.20212394
- VernacularTitle:香砂六君子汤加减敷贴防治消化道肿瘤中、高致吐性化疗后副反应的临床观察
- Author:
Fei SU
1
;
Yan-ni LOU
1
;
Li-ya LI
1
;
Zhi-qiang CHENG
1
Author Information
1. China-Japan Friendship Hospital，Beijing 100029，China
- Publication Type:Research Article
- Keywords:
Xiangsha Liujunzi Tang;
gastrointestinal tumor;
external treatment of traditional Chinese medicine;
chemotherapy;
gastrointestinal reaction
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(23):104-110
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of external application of modified Xiangsha Liujunzi Tang in improving gastrointestinal reaction，immune function， and quality of life in patients with gastrointestinal tumors after moderately/highly emetogenic chemotherapy. Method:A total of 140 inpatients （from January 2018 to May 2021） with gastrointestinal malignancies diagnosed by the Oncology Department of Integrated Traditional Chinese and Western Medicine of China-Japan Friendship Hospital and treated with moderately/highly emetogenic chemotherapy were randomly divided into an experimental group （n=70） and a control group （n=70） according to the Good Clinical Practice （GCP）. Participants were given routine antiemetic treatment once 20 minutes before chemotherapy （tropisetron 5 mg + dexamethasone 5 mg or methylprednisolone 40 mg）. On this basis， the patients in the experimental group were treated with external application of modified Xiangsha Liujunzi Tang for 1 week on the second day after chemotherapy （the selected points were Zhongwan， Neiguan and Zusanli， 6 hours a day， and the application was changed every day）， and the patients in the control group were applied with comfort patch at the same time. The gastrointestinal reaction grade， subset concentration of lymphocytes， and Karnofsky score in two groups before and one week after chemotherapy were recorded， and all data were analyzed by SPSS 19.0 statistical software. Result:The grades of chemotherapy-related gastrointestinal reaction in two groups after treatment decreased as compared with that before treatment （P<0.05）. The experimental group was superior to the control group after treatment in terms of grade decrease （P<0.05）. The total response rate of the experimental group was 81.43% （57/70）， higher than 62.86% （44/70） in the control group （χ2=9.73， P<0.05）. Stratified analysis was performed on the experimental group. Compared with the conditions before treatment， the grade of gastrointestinal reaction in patients with esophageal cancer and colorectal cancer of the experimental group decreased after treatment （P<0.05）， and that in patients of different genders decreased after treatment （P<0.05）. The results of immune function showed that there was no significant difference in the concentrations of CD3+， CD4+， CD8+， and NK cell subsets of the control group before and after treatment， while the concentrations of CD3+， CD4+， and NK cell subsets of the experimental group were higher than those before treatment and even superior to those in the control group （P<0.05）. The Karnofsky score of quality of life in the experimental group was higher than that in the control group， with quality of life improved （P<0.05）. Conclusion:External application of modified Xiangsha Liujunzi can improve the gastrointestinal reaction，immune function， and quality of life of patients with gastrointestinal tumors after moderately/highly emetogenic chemotherapy.
