Advances in Research on Active Ingredients and Related Pharmacology of Periplaneta americana
10.13422/j.cnki.syfjx.20210245
- VernacularTitle:美洲大蠊的有效成分及相关药理学研究进展
- Author:
Yang-yang GAO
1
;
Fu-neng GENG
1
;
Si-min CHEN
1
;
Xiu-ying MA
2
Author Information
1. College Pharmacy， Chengdu University of Traditional Chinese Medicine， Chengdu 611137， China
2. Sichuan Key Laboratory of Medicinal Periplaneta americana， Sichuan Good Doctor Panxi Pharmaceutical Co.Ltd.， Chengdu 611137， China
- Publication Type:Research Article
- Keywords:
Periplaneta americana;
chemical composition;
pharmacological action;
clinical application;
quality control
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(4):240-250
- CountryChina
- Language:Chinese
-
Abstract:
Periplaneta americana is one of the important basic medicinal materials of traditional Chinese medicine "fei lian". The traditional functions mainly include promoting blood circulation， sore muscles， diuresis， spleen and phlegm. Because of its exact curative effect， proprietary Chinese medicines， which are mainly used as raw materials， are widely used in clinical practice， especially in the repair of various wounds. The drug has not been included in the Chinese Pharmacopoeia. The local standard is only based on the alanine content of total amino acids. The physiologically active small peptides， nucleosides， proteins and other substances have not been obtained. Qualitative or quantitative control. In recent years， peptide monomers isolated from the P.americana， such as antimicrobial peptides， neuropeptides， and diuretic peptides， have strong pharmacological activities such as antibacterial， antitumor， and muscular neurotrophic， and dihydroisocoumarins are also irritating. Dermal Dermal fibroblasts produce collagen. Based on this， this paper uses CNKI， Wanfang Database and Pubmed Database to search the relevant research literatures of P.americana from 1984 to 2019， and systematically analyzes the current research of P.americana from three aspects： chemical composition-pharmacological action-clinical application. Interpretation provides reference for the further development of the drug and the development of more specific and stable quality control standards for its proprietary Chinese medicines.
