Pathological Mechanism of PPs in Immune-related Enteropathy and Regulatory Effect of Traditional Chinese Medicine Polysaccharides
10.13422/j.cnki.syfjx.20202403
- VernacularTitle:PPs在免疫相关肠病中的病理机制及中药多糖的调控作用
- Author:
Xiu-lan PU
1
;
Mei-si LIN
1
;
Rui-feng LUO
1
;
Qi-yan CHEN
1
;
Ling-ling DONG
1
;
Da-sheng LIN
1
;
Fei GAO
1
Author Information
1. School of Pharmacy， Chengdu University of Traditional Chinese Medicine（TCM）， State Key Laboratory of TCM Resources in Southwestern China， Chengdu 611137， China
- Publication Type:Research Article
- Keywords:
traditional Chinese medicine polysaccharides;
intestinal Peyer's patches;
ulcerative colitis;
mechanism
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(4):216-224
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal Peyer's patches （PPs） are local immune tissues of the intestine， which are considered to be the main induction site of the intestinal mucosal immune response， and closely related to immune-related refractory enteropathies， such as ulcerative colitis and Crohn's disease. In recent years， more and more scholars have tried to find a new breakthrough for treating refractory enteropathies with a limited efficacy of clinical interventions through in-depth study of the relationship between PPs and enteropathy. Traditional Chinese medicine （TCM） polysaccharides are considered to be a key component for immune regulation with TCM. Modern studies show that TCM polysaccharides have a significant positive intervention effect on the structure and function of PPs， with good development prospects. Based on this， this paper focuses on PPs and intestinal-related diseases， and systematically introduces the physiological structure of PPs and their drug delivery mechanism， and summarizes the interactions of PPs with effect on immune-related enteropathies， analyze of current studies and prospects of effect of TCM polysaccharides in intervening intestinal disease and its dysfunction by regulating PPs， with the aim to provide new strategies for basic studies and clinical treatment of immune-related refractory enteropathies from the perspective of PPs， and new ideas for basic studies and clinical studies on effect of TCM polysaccharides in intervening enteropathies.
