Advances in Basic Studies on Antitumor Effect and Underlying Molecular Mechanisms of Sinomenine
10.13422/j.cnki.syfjx.20212524
- VernacularTitle:青藤碱抗肿瘤作用与分子机制研究进展
- Author:
Lin TANG
1
;
Ye LIN
1
;
Le-ping LIU
1
;
Xiao-shan LU
1
;
Sheng-tao HU
1
;
Er-bing ZHANG
1
;
Feng ZHANG
1
;
Zong-shun DAI
1
;
Hou-pan SONG
1
;
Yu-ming HUANG
2
;
Xiong CAI
1
;
Liang LIU
3
Author Information
1. Institute of Innovation and Applied Research in Chinese Medicine， Hunan University of Chinese Medicine， Changsha 410208， China
2. Hunan Zhengqing Pharmaceutical Group Co. Ltd.， Huaihua 418000， China
3. State Key Laboratory of Quality Research in Chinese Medicine， Macau University of Science and Technology， Macau 999078， China
- Publication Type:Research Article
- Keywords:
sinomenine;
anti-tumor;
mechanisms of action;
signaling pathways;
apoptosis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2021;27(4):175-185
- CountryChina
- Language:Chinese
-
Abstract:
Tumors are new organisms formed by uncontrollable cell proliferation of local tissues driven by various oncogenic factors. The cause of tumors is unknown with life-threating outcome. Tumors can be classified into benign tumors， borderline tumors， and malignant tumors according to their pathological properties. Among them， malignant tumor is commonly known as cancer， with no specific medicines or reliable cure means， so this is a hot spot and difficult point in current medical research. In ancient literatures， there are many records about the efficacy of Chinese herbal medicine in treating tumor， and modern pharmacological researches have shown that more and more active ingredients of traditional Chinese medicine（TCM） have gradually highlighted their inhibitory effect on various types of tumor. Caulis sinomenii has been used for treatment of rheumatic diseases in TCM for a long history. Sinomenine is a major bioactive alkaloid presented in C. sinomenii， which has demonstrated a wide range of pharmacological activities such as anti-inflammation， immunosuppression， analgesia and sedation， and due to its slightly soluble in water， it is commonly used in clinic in the form of hydrochloride， with its commercial name of Zhengqing Fengtongning. Recent studies show that sinomenine alone or combined with chemoradiotherapy can inhibit growth of several tumors significantly or in a synergistic way， so it is termed as an inhibitor of tumors. Anti-tumor effect of sinomenine involve inhibition of tumor cell proliferation， induction of tumor cell apoptosis， blockade of tumor cell cycle， suppression of tumor invasion and metastasis， induction of autophagy of tumor cells， and reversal of multidrug resistance of tumor cells. Upon combination with nanomaterials， it can enhance efficiency and reduce toxicity. Here we summarized and reviewed recent advances on basic anti-tumor research of sinomenine， and then made a classification and description according to its in vivo and in vitro pharmacological action and mechanism of action， so as to elucidate the great potential of sinomenine as a promising anti-tumor drug， and provide reference for further research on its anti-tumor mechanism.
